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GBA Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

Interleukin - 1 (IL-1)

Secreted By Macrophages

A

Local: Inflammation Induction
Systemic: Fever, Acute Phase Response.
Endothelium expression of Adhesion molecules.
Induces Chemokine secretion for WBCs recruitment.

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2
Q

Interleukin - 2 (IL-2)

Secreted By T-cells

A

Proliferation of T cells (Autocrine) and NK cells.

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3
Q

Interleukin - 3 (IL-3)

Secreted By T-cells

A

Growth Factor: Stimulation of all Leukocytes colony types but Lymphocytes. Like GM-CSF

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4
Q

Interleukin - 6 (IL-6)

Secreted By Macrophages

A

Causes Fever and Stimulation of Acute Phase Proteins.

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5
Q

Interleukin - 8 (IL-8)
Secreted By Macrophages
“Clean up on aisle 8”

A

Major Chemokine for Neutrophills ( Basophils and Lymphocytes).
“Clean up on aisle 8” - IL8 for Neutrophills cleaning up infection.

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6
Q

Interleukin - 12 (IL-12)

Secreted By Macrophages

A

Induces CD4+ T Helper cells to differentiate into TH1.

Activates NK cells.

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7
Q

Tumor Necrosis Factor - TNF-alpha

Secreted By Macrophages

A

Fever. Activates Endothelium. Causes WBC recruitment, Vascular Leak

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8
Q

Tumor Necrosis Factor - TNF-alpha
Abnormal Pathologic actions (2)
Secreted By Macrophages

A

In Malignancy - Cachexia

In TB - Maintains Granulomas

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9
Q

Common for IL1, IL6 and TNF-Alpha

A

Secreted By Macrophages
Mediation of Fever and Sepsis
“Acute Cytokines”

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10
Q

Common for IL8, IL12

A

Secreted By Macrophages

Cause Recruitment of further WBCs in inflammation for Infection clearance.

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11
Q

Interferon-Gamma

Secreted by? When?

A

NK cells and TH1 cells in response to Antigen or IL-12 from Macrophages.

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12
Q

Interferon-Gamma Stimulates _____ to kill phagocytosed Pathogen.

A

Interferon-Gamma Stimulates Macrophages to kill phagocytosed Pathogen.

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13
Q

Interferon-Gamma: Inhibits differentiation of ___ cells

A

Interferon-Gamma: Inhibits differentiation of TH2 cells

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14
Q

Interferon-Gamma: Activates ___ cells to kill _____ cells.

A

Interferon-Gamma: Activates NK cells to kill Virus-Infected cells.

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15
Q

Interferon-Gamma: Increases ___ expression and antigen presentation in ___ cells.

A

Interferon-Gamma: Increases MHC expression and antigen presentation in All cells.

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16
Q

Interleukin - 4 (IL-4)

Secreted from ___ cells and Causes T cells differentiate to ___ cells.

A

Interleukin - 4 (IL1-4)

Secreted from TH2 cells and Causes T cells differentiate to TH2 cells.

17
Q 
Interleukin - 4 (IL-4)
Promotes growth of \_\_\_ cells. Enhances class switching to \_\_\_ and \_\_\_ .
A 
Interleukin - 4 (IL1-4)
Promotes growth of B cells. Enhances class switching to IgE and IgG.
18
Q

Interleukin - 5 (IL-5)

Secreted by ___, Promotes growth and differentiation of ___ cells and ___phils.

A

Interleukin - 5 (IL1-5)

Secreted by TH2, Promotes growth and differentiation of B cells Eosinophils.

19
Q 
Interleukin - 5 (IL-5)
Enhances class switching to \_\_\_ .
A 
Interleukin - 5 (IL1-5)
Enhances class switching to IgA .
20
Q

Interleukin - 10 (IL-10)
Secreted by ___ cells - ___ Inflammatory Response.
Same action as ___ .

A

Interleukin - 10 (IL1-10)

Secreted by TH2 cells - Attenuates Inflammatory Response. Same action as TGF-beta.

21
Q

Interleukin - 10 (IL-10)

Secreted by ___ cells - Decreases expression of _____ and ___ Cytokines.

A

Interleukin - 10 (IL1-10)

Secreted by TH2 cells - Decreases expression of MHCII and TH1 Cytokines.

22
Q

Interleukin - 10 (IL-10)

Secreted by ___ cells and also by ___

A

Interleukin - 10 (IL1-10)

Secreted by TH2 cells and also by T regulatory cells.

23
Q

Interleukin - 10 (IL-10)

Inhibits ___ and ___ cells.

A

Interleukin - 10 (IL1-10)

Inhibits Macrophages and Dendritic cells.

24
Q

Common for IL-4, IL-5 and IL-10

A

IL4,IL5 and IL10 are secreted by TH2 cells.

25
Q

Common for IL-2,IL-3

A

IL-2,IL-3 are secreted by all T cells.

26
Q

Interleukin - 7 (IL1-7)

Secreted by Stromal cells allows for____

A

B and T cells differentiation

27
Q

Costimulation of B and T cells: 3rd Signal

TH2 Cytokines released for B cell -

A

IL4 - Growth of B cells + Isotype Switch to IgE and IgG
IL5 - Growth of B cells + Isotype Switch to IgA
(TH2 Self Stimulation is by IL4)

28
Q

Long-lived plasma cells in the bone marrow are receiving 2 important stimuli for survival from stromal cells:

A

BAFF - Interacting with BCMA in Plasma cell

IL6 - IL6R on Plasma cell

29
Q

Costimulation of B and T cells: 3rd Signal

TH1 Cytokines released for B cell -

A

IFN-γ: Isotype Switch to IgG3 and IgG1

Promotion of Phagocytosis

30
Q

Chemokines: (CXC Class)

Target of IL-8

A

Neutrophil

31
Q

Chemokines: (CC Class)

Target of RANTES

A

Monocytes Mostly (T cells, Basophils and Eosinophils also)

32
Q

Chemokines: (CXXXC Class)

Target of Fractalkine

A

T cells and Monocytes

33
Q

Chemokines:(C Class)

Target of Lymphotactin

A

Lymphocytes

GBA Immunology (15 decks)

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