Wednesday - Adrenal Phys - Trachte Flashcards
What hormone are needed for cortisol release?
Corticotropin Releasing Hormone (CRH) –> ACTH –> Cortisol (has negative feedback to others)
4 major effects of cortisol:
immune suppression
gluconeogenesis (raise blood glucose levels. lack of cortisol –> hypoglycemia)
protein catabolism
lipolysis
CRH is made where?
acts where?
half life:
receptor type:
Hypothalamus
Anterior pituitary
9 minutes
Gs –> cAMP
CRH leads to synthesis of what?
that is cleaved into what?
pro-opiomelanocortin (POMC)
Melanocyte Stimulating Hormone
ACTH
lipotropin
ACTH binds to what receptor?
what type of g protein is it?
Where is it located?
melaoncortin
Gs –>cAMP
adrenal cortex
What does ACTH cause in the adrenal cortex
side chain cleavage, turning cholesterol into pregnelolone
Where in the cell are glucocorticoid receptors?
What cells have them?
What do they do?
cytosol, just floatin’ around
almost every cell
homodimer –> transcription factor –> regulate immune response and metabolism (6000 genes effected)
Mineralcorticoid receptor is found where?
collecting duct, colon, sweat glands
There is a lot of cortisol and not much aldosterone. How does an aldosterone sensitive tissue have it’s response since they have the same affinity
turns the cortisol to cortisone, which has very little affinity for the Mineralcorticoid receptor
Main mineral coorticoid and effects of it
Aldosterone
water retention
3 Androgens that bind to androgen receptor
dehyroepiandrosterone
androstenedione
testosterone
How does cortisol get transported
10% free
90% bound to to transcortin or albumin
what does cortisol do to bones?
decreases osteoblasts -> osteoperosis
Cushing disease =
Cushing syndrome =
What to you look like?
disease = pituitary adenoma --> ACTH secretion syndrome = too much cortisol --> decrease ACTH
a fool
- buffalo hump
- tine skin
- potbelly and skinny legs
- moon face?
What time are cortisol levels highest?
morning
