Thursday - Thyroid path - Krafts Flashcards
T4 goes up a little, what happens to TSH
Goes down a lot.
or other way T4 down a little, TSH up a lot
T4 and TSH labs of primary hyperthyroidism
Secondary?
T4 high
TSH low
T4 high
TSH high
T4 and TSH labs of primary hyporthyroidism
Secondary?
problem is somewhere other than thyroid galnd
T4 low
TSH high
T4 low
TSH low
3 antibodies that could be in Hashimotos or Grave disease
anti-peroxidase - usually hashimotos's anti-thyroglobulin - either anti-TSH receptor - either, but in Graves, it stimulates
Systemic signs of hyperthyroidism
Weight loss, warm fast heart tremor diarrhea eyelid stays open when eyes move down
Most common cause of Hyperthyroid
others?
Graves disease
multinodular goiter
thyroid adenoma/carcinoma
pituitary adenoma
stroma ovarii
Systemic signs of hyporthyroidism
fatigue, weight gain slow heart delayed reflexes dry skin, hair loss no appetite deep voice Myxedema - under eyes mental changes
Congenital hypothyroidism is due to:
treatment:
genetic or iodine deficient
Thyroid hormone or iodine
Autoimmune thyroiditis called:
symptom:
Labs?
antibodies?
Hashimoto's painless, large thyroid low T4, high TSH anti-peroxidase anti-thyroglobulin
Pathophys of Hashimoto’s
T cells recognize thyroid as antigen –> stimulate b cells to make antibodies
De Quervain thyroiditis
symptoms
histo:
Big, SORE thyroid recent URI had hypERthyroid jaw pain it's self limiting
granulomas, lymphocytes
Histo findings of hashimoto’s
inflammation
large germinal centers
Hürthle cells - big, pink, inflamed cells
Histo finding of Silent thyroiditis
cause?
just lots of lymphycytes
don’t know, HLA, autoimmune?
Hypothyroid with a hard mass of fibrous tissue called?
Reidel thyroiditis
- painless
Triad of symptoms seen in Graves disease
Hyperthyroid
Opthalmopathy
Dermopathy
- thick skin/rash
