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WBC Abnormality And Anomaly Flashcards

0
Q

Last stage of mitosis

A

Myelocyte

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1
Q

Increase in concentration of WBC

A

Luekocytosis

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2
Q

Term used to identify very immature cells seen on PBS

A

Blast

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3
Q

First morphologic stage where you can differentiate neutrophilic, eosinophilic and basophilic

A

Myelocyte

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4
Q

High NC ratio, finely reticular chromatin with nucleoli

A

Myeloblast

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5
Q

Blue cytoplasm with azurophilic granules

A

Promyelocyte

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6
Q

Nuclear remnants of lympho

Thumbprint appearance

A

Smudge cell

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7
Q

Classification of leukocytes

A

Granulation
Segmentation
Function

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8
Q

Lymphocyte Seen in nonmalignant reactive disorders

A

Variant lymphocyte

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9
Q

Stage: Synthesis of tertiary granules

A

Metamyelocyte

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10
Q

Formation of secretory vesicles

A

Band

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11
Q

Proposed by the NCCLS as the term of choice for this type of lymphocyte

A

Variant lymphocyte

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12
Q

Also called plasmacytoid lymphocyte and Turk irritation cell

A

Type 1

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13
Q

Macropolycyte

5-10 lobes. Seen in megaloblastic anemia

A

Hypersegmented neutrophils

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14
Q

Ruptured WBC with bare nucleus

Due to improper forceful smearing

A

Smudge cells

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15
Q

Vacuolated cell may be seen in

A

Severe infections
Chemical poisoning
Leukemia

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16
Q

Dark blue, ovoid non granular with russel bodies that produces proteins

A

Plasma cell

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17
Q

Seen in 88% of patients with cancer

A

Hairy cell

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18
Q

A phagocytic monocyte with engulfed nucleus of another cell

A

Tart cell

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19
Q

Predominant type seen in IM

Fried egg and flared skirt appearance

A

Type II

Infectious mononucleosis

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20
Q

A phagocytic neutrophil that has ingested an altered homogenous globular nuclear mass of destroyed cell

A

Lupus erythematosus cell

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21
Q

Wrinkled or onion skin like appearance

A

Gaucher bodies

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22
Q

Lymphocyte with notched lobulated or segmented or clover leaf like nucleus in chronic lymphocyte or lymphatic leukemia

A

Reider cells

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23
Q

Most valuable and reliable criterion for describing whether a WBC is mature or immature

A

Nuclear chromatin pattern

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24
Q

Functionally immunocompetent. Probably of B Cell origin

A

type 1/ plasmacytoid lymphocyte

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25
Q

Characterized by the failure of the nucleus of neutrophils to segment or lobulate

A

Pelger huet anomaly

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26
Q

The appearance of this inclusions is transient only

A

Dohle bodies

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27
Q

Presence indicates increased cell fragility or cell destruction

A

Smudge cell

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28
Q

Tart cell may be seen in

A

Drug sensitivity

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29
Q

Granulation results from an abnormal deposition and storage of mucopolyssacharide
Cytoplasmic granulation is not transient or related to an infection

A

Alder reilley anomaly

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30
Q

Genetic qualitative disorder with abundant sudanophilic inclusions

A

Jordan anomaly

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31
Q

Found in neutrophils as irregular, round or oval blue staining cytoplasmic inclusions
About the size of cocci 2um

A

Dohle bodies

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32
Q

Most common increase. Non malignant

A

Increase neutrophil

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33
Q

With holes or vacuoles in the cytoplasm

Sign of degeneration

A

Vacuolated cell

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34
Q

Rare autosomal dominant, qualitative leukocyte abnormality

A

May Hegglin anomally

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35
Q

Greenish pigment

A

Sulfhemoglobin

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36
Q

Test used to differentiate dohle bodies and May hegglin anomaly

A

Periodic acid schiff

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37
Q

Normal size of WBC

A

9-15um

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38
Q

Believed to be altered primary granules

Color dar blue to black

A

Toxic granulation

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39
Q

Characterized by dense azurophilic granulation in all types of leukocytes

A

Alder Reilly anomaly

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40
Q

Czediak higashi patients display?

A

Partial albinism

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41
Q

Pince Nez form of neutrophil nucleus

A

Pelger huet anomaly

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42
Q

First describe in association with progressive muscular dystrophy and subsequently icthyosis

A

Jordan anomaly

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43
Q

Rod like bodies when stain reddish purple in the cytoplasm of myeloblast in acute myelocutic leukemia

A

Auer bodies

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44
Q

May hegglin Demonstrate?

A

Pale blue, spindle-shaped inclusions (2-5um)

45
Q

Rare condition in which both fandom and directed movement of the cells are defective

A

Lazy leukocyte syndrome

46
Q

Results from the proteinacious material produced by immune globulins
Grape like structure

A

Russel bodies

47
Q

Granules are believed to be normal in content but abnormally packaged

A

Czediak Higashi

48
Q

Flame cells or flaming plasmacytes

A

Russel bodies

49
Q

Accumulation of ganglioside and glycolipid

50
Q

Release of cell from the marrow to the peripheral blood is poor

A

Lazy leukocyte syndrome

51
Q

Alder Reilly is associated with?

A

Skeletal dystrophy

Gargoylism

52
Q

Reduced form of iron

53
Q

Gaucher bodies are the accumulation of what enzyme

A

Glucocerobroside

54
Q

Bodies with glycoprotein component found in dysproteinemias

A

Dutcher bodies

55
Q

Foamy or soap suds appearance

A

Niemann-Pick

56
Q

Deficiency associated with tay sach

A

Hexosaminidase type A

57
Q

Stain positively for fat

A

Jordan anomaly

58
Q

Disease association of dohle bodies

A

Scarlet fever

59
Q

Best time to take iron supplements

A

Early morning

60
Q

Transport protein for iron

A

Transferrin

61
Q

Most functional protein in human

A

Hemoglobin

Myoglobin

62
Q

Storage form of iron

A

Ferritin

Hemosiderin

63
Q

Other tern for heme

A

Protoporphyrin IX

64
Q

Respiratory pigment

A

Hemoglobin

65
Q

Chromosome 11

A

Beta, delta epsilon, gamma

66
Q

Production of globin chain takes place in what stage

A

Pronormoblast

67
Q

Diagnostic of acute myelogenous leukemia

68
Q

Granules that kills bacteria once engulfed

A

Myeloperoxidase

69
Q

Competes with iron supply

A

Lactoferrin

70
Q

Translated more efficiently that alpha globin mRNA

A

B-globin mRNA

71
Q

1 RBC

72
Q

Gower II

A

Alpha and epsilon

73
Q

Iron that is incorporated into hemoglobin molecule

74
Q

Heme synthesis occurs in what part of the body?

A

Bone marrow

75
Q

Major organelle of heme synthesis

A

Mitochondria

76
Q

1st three months of embryonic development

77
Q

Oxygenated hemoglobin?
What color?
Seen in?

A

Oxyhemoglobin
Bright red
Arterial blood

78
Q

Unable to act as an oxygen carrier

A

Non functional Hb

79
Q

Gower 1

A

Zeta and epsilon

80
Q

Irreversible reaction. Hypoxia results

A

Carboxyhemoglobin

81
Q

Color of carboxyhemoglobin

Seen in

A

Cherry red

Blood and skin

82
Q

What is my favorite color

A

Flesh pink

83
Q

Contain ferric. Reaction is reversible

A

Methemoglobin

84
Q

Degrade bacterial cell wall

86
Q

Nuclear remnants of granulocytic cells with net like chromatin pattern

A

Basket cell

87
Q

Genetic disorder characterized by giant cytoplasmic granules in the phagocytes and lumphocytes

A

Czediak-Higashi syndrome

88
Q

Linear projections of primary, azurophilic granules

A

Auer bodies

89
Q

Large hypogranular platelets are seen

A

May Hegglin Anomaly

90
Q

Infectious mononucleosis cell

91
Q

Cartwheel pattern

A

Plasma cell

93
Q

Plays a major role in parasitic infections and in hypersensitivity reaction

A

Eosinophil

94
Q

Body soldiers

A

Leukocytes

95
Q

Kidney or peanut shaped

A

Metamyelocyte

97
Q

Seen im hexagonalbipyramidal crystals

A

Charcot leyden crystals

98
Q

Neutral cytoplasm with no nucleus that is divided by thin filaments containing no internal chromatin into 2-5 lobes

A

Segmented neutrophil

99
Q

Sieve like appearance of chromatin

A

Myeloblast

100
Q

Robin egg blue cytoplasm

A

Lymphocyte

101
Q

Slight clumping chromatin

A

Promyelocyte

103
Q

Juvenile stage

A

Metamyelocyte

103
Q

Tertiary granules?

A

Gelatinase granules

104
Q

May appear as undefined blast cell

A

Immature monocyte

105
Q

Caused by a mutation of the lamin B

A

Pelger huet anomaly

106
Q

Granules that play a major role in the cell’s ability to damage parasitic invaders

A

Major basic protein

107
Q

Structural abnormality in the Myeloperoxidase gene

A

Alder reilly anomaly

108
Q

Include giant lysosomal granules in granulocytes, monocyte and lymphocytes

A

Czediak higashi

109
Q

Important marker on inflammation. Induced by increases in granulocyte CSF

A

Toxic granulation

110
Q

Charcot leyden is composed of

A

Lysophospholipase

111
Q

Stains light pink with many small specific granules that give cytoplasm a grainy appearance

A

Neutrophil

111
Q

May demonstrate pseudopods

113
Q

S, C or U shaped

114
Q

Dawn of neutrophilia

Hematology (7 decks)

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