Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology > Primary Hemostasis, Platelet Function. Lab Tests > Flashcards

Primary Hemostasis, Platelet Function. Lab Tests Flashcards

1
Q

Cellular elements of hemostasis

A

Vascular intima
Extracellular tissue factor bearing cells
Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Plasma components of hemostasis

A

Coagulation and fibrinolytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Structure of blood vessel wall

A

Vascular initima

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Rhomboid and contiguous

A

Endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Anticoagulant properties of Vascular intima

A 
Lamina propia
Nitric oxide
Heparin sulfate
TFPI
Thrombomodulin
PGI2 or prostacyclin
TPA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Activates fibrinolytic serum. Dissolves clot

A

TPA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Vasodilator, inhibits platelet activation

A

Prostacyclin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Activates protein C pathway. Digest factor Va and VIIIa

A

Thrombomodulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Inactivates coagulation factor VIIa

A

TFPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Inactivates extrinsic factor

A

TFPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Retards coagulation by activating antithrombin

A

Heparin sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Counteracts vasoconstriction

A

Nitric oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Relaxing factor

A

Nitric oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Promotes platelet activation and adhesion

A

Collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Origin of collagen

A

Fibroblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Activates fibrin bound plasminogen to form plasmin

A

TPA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Digest thrombus and restore blood flow

A

Plasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Inhibits activation of fibrinolytic system

A

PAI-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Adhesion molecules

A

P-selectin
ICAM
PECAM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Induce vasoconstriction

A

Smooth muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Who secretes vWF

A

Endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Promotes leukocyte binding

A

ICAM

PECAM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Promotes platelets and leukocytes binding

A

P selectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Platelets roll and cling to nonplatelet surfaces

A

Adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Platelet adheres to each other

A

Aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Platelets discharge the contents of their granules

A

Secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Absence of GP IIb/IIIa

A

Glanzmann thrombostemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Absence of Gp Ib/IX

A

Bernard soulier syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Where is vWF being stored

A

Weible palade bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Bind vWF

A

GP Ib/IX receptor

31
Q

For jigsaw puzzle effect

A

Pseudopod

32
Q

For crosslink to other platelet

A

GP IIb/IIIa

33
Q

Requires fibrinogen

A

Aggregation

34
Q

Requires extensive damage

A

Aggregation

35
Q

Reversible aggregation

Platelets adhere loosely to each other

A

Primary aggregation

36
Q

Irreversible aggregation

Release of substance that acts as antagonist

A

Secondary aggregation

37
Q

Substances that promotes coagulation

A

HMWK
Fibrinogen
Factor V
Factor VIII:vWF

38
Q

Substances that promotes aggregation

A

ADP
Calcium
PF4
Thrombospondin

39
Q

Promotes vasoconstriction

A

Serotonin

Thromboxane A2

40
Q

Promotes vascular repair

A

PDGF

B-thromboglobulin

41
Q

Plasma precursors

A

Plasminogen

42
Q

Plasma inhibitors

A

Alpha-2-antiplasmin

43
Q

Complement system inhibitors

A

C1 esterase inhibitor

44
Q

Positive result of capillary fragility test

A

Petechiae

45
Q

Methods of Capillary fragility test

A

Tourniquet test
Rumple Leed
Gothlin
Quick

46
Q

4+ petechiae

A

> 50

47
Q

1+ petechiae

A

0-10

48
Q

2+ petechiae

A

11-20

49
Q

3+ petechiae

A

21-50

50
Q

Pinpoint hemorrhagic spots

A

Petechiae

51
Q

Correlates with the degree of thrombocytopenia

A

Capillary fragility test

52
Q

Original test for platelets

A

Bleeding time

53
Q

Normal value of Duke method

A

2-4mins

54
Q

Normal value of Ivy method

A

2-9mins

55
Q

Factors affecting bleeding time

A

Vascular integrity
Platelet function
Platelet count

56
Q

2 cuts in volar surface of hand

A

Ivy method

57
Q

Reason why platelet count is difficult

A 
Platelets:
.easily adhere to foreign surface
.Easily disintegrate
.difficult to distinguish from debris
.unequal distribution in circulation
58
Q

Whole blood is diluted with diluting fluid in RBZc pipet and counted in hemocytometer

A

Direct platelet count

59
Q

Platelets are counted in relation to 1000 RBC in the PBS

A

Indirect platelet count

60
Q

Indirect methods

A

Damashek
Fonio
Olef

61
Q

Direct methods

A

Guy and Leake
Reese Ecker
Brecker cronkite
Unopette

62
Q

Direct using light microscope

A

Reese Ecker

Guy and Leake

63
Q

Diluting fluid of Reese Ecker

A

Sodium citrate
BCB
Distilled water

64
Q

Guy and Leake diluting fluid

A

Sodium citrate or oxalate
Crystal violet
Formalin

65
Q

Diluent of brecker cronkite and use of diluent

A

1% ammonium oxalate

Hemolyzes RBC

66
Q

Damashek diluent

A 
BCB
Sodium citrate 
Distilled water
Formalin
Sucrose
67
Q

Best indirect method

A

Olef

68
Q

Diluent of Fonio

A

14% MgSO4

69
Q

Inhibits cyclopxygenase enzyme

A

Aspirin

70
Q

Inhibit GP IIb/IIIa

A

Tirofibom

71
Q

Inhibits ADP receptor

A

Clopidogrel bisulfate

72
Q

Inhibit circulating thrombin

A

Heparin

73
Q

Inhibit thrombin attach to fibrin

A

Hirudin

74
Q

Process by which blood is maintained within the vessel walls

A

Hemostasis

Hematology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions