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Pathoma > WBC > Flashcards

WBC Flashcards

1
Q

CD34+

A

hematopoietic stem cell

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2
Q

CD16

A

Fc receptor

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3
Q

GM-CSF/G-CSF boost ___ numbers

A

neutrophil

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4
Q

most sensitive cell to radiation

A

lymphocyte

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5
Q

left shift characterized by decreased ___ ___ on immature neutrophils

A

Fc receptors (CD16)

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6
Q

high cortisol state increases ___ count

A

neutrophil (due to demargination)

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7
Q

eosinophilia increased in ___ lymphoma

A

hodgkin (due to IL-5)

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8
Q

basophilia increased in ___ (leukemia)

A

CML

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9
Q

___ ___ (bacteria) produce lymphocytosis

exception

A

b pertussis

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10
Q

lymphadenopathy due to hyperplasia of the ___

A

paracortex

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11
Q

splenomegaly due to hyperplasia of the ___ ___ ___

A

periarterial lymphatic sheath

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12
Q

what is the cell of infectious mononucleosis

A

CD8+ (atypical lymphocytes)

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13
Q

monospot test detects Ig___ antibodies

A

IgM

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14
Q

do not give ___ to patients with mono

A

ampicillin (rash)

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15
Q

EBV remains dormant in ___ cells

A

B

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16
Q

> 20% blast cells

A

acute leukemia
(1-2% WNL)

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17
Q

how does acute leukemia present? (3)

A

anemia
thrombocytopenia
neutropenia

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18
Q

ALL stains positive for ___

A

TdT (DNA polymerase)

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19
Q

ALL associated with ___

A

DS

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20
Q

AML blasts contain ___, which appears as an ___ ___(s)

A

MPO
auer rod

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21
Q

T-ALL contain the markers between CD_ - CD_

A

CD2 - CD8

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22
Q

t(12,21)

A

ALL

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23
Q

t(9,22) can be seen in which leukemias

A

ALL (severe)
CML (most common)

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24
Q

ALL requires prophylaxis to ___ and ___

A

scrotum
CSF

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25
Q

t(15,17)

A

APL
(retinoic acid receptor disrupted)

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26
Q

APL Tx

A

all-trans retinoic acid

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27
Q

auer rods increase risk for ___

A

DIC

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28
Q

acute monocytic leukemia presentation

A

gingival abnormality

29
Q

acute megakaryoblastic leukemia associated with ___

A

DS

30
Q

CLL co-expresses CD_ and CD_

A

CD5
CD20

31
Q

hairy cell leukemia positive for ___

A

TRAP

32
Q

hairy cell leukemia Tx

A

cladribine (adenosine deaminase inhibitor)

33
Q

___ is associated with HTLV-1

A

ATLL

34
Q

mycosis fungoides

A

neoplastic proliferation of CD4+ within the epidermis

35
Q

BCR-ABL fusion protein relevance

A

increased TK activity

36
Q

polycythemia vera associated with what mutation?

A

JAK2 kinase

37
Q

CML Tx

A

imatinib (TK inhibitor)

38
Q

CML is LAP ____

A

negative

39
Q

what can cause itching after bathing?

A

polycythemia vera

40
Q

essential thrombocythemia associated with what mutation?

A

JAK2 kinase

41
Q

myelofibrosis can present with what on blood smear?

A

dacrocytes (tear-shaped)

42
Q

myelofibrosis associated with what mutation?

A

JAK2 kinase

43
Q

CD18 mutation in ___

A

LAD

44
Q

follicular hyperplasia seen in ___ and early ___

A

RA
HIV

45
Q

paracortex hyperplasia seen in ___ ___

A

infectious mono

46
Q

t(14,18)

A

follicular lymphoma
excess Bcl2

47
Q

t(11,14)

A

mantle cell lymphoma
excess cyclin D

48
Q

t(14,18) Tx

A

rituximab (anti-CD20)

49
Q

t(14,18) can progress to what?

A

diffuse large b-cell lymphoma

50
Q

follicular hyperplasia vs lymphoma

A

follicular invasion
NO tingible body macrophages
Bcl2 expression

51
Q

cyclin D function

A

G1 > S progression

52
Q

what lymphoma is associated with chronic inflammation

A

marginal zone
(hashimoto, SS, h pylori)

53
Q

“starry sky” appearance

A

burkitt lymphoma
t(8,14)

54
Q

t(8,14)

A

burkitt lymphoma
c-myc expression

55
Q

sporadic burkitt lymphoma appears where in the body?

A

abdomen (vs African in mandible)

56
Q

reed-sternberg cells

A

hodgkin lymphoma

57
Q

hodgkin lymphoma is CD_ and CD_ positive

A

CD15
CD30

58
Q

most common HL

A

nodular sclerosis (hard nodules separated by fibrosis)

59
Q

IL-_ is elevated in MM

A

IL-6

60
Q

IL-_ is elevated in AS

A

17

61
Q

“punched-out” lytic lesions

A

MM

62
Q

M spike denotes what?

A

monoclonal Ig
(common in MM)

63
Q

rouleaux formation on blood smear

A

MM

64
Q

amyloid in MM

A

AL (light chain)

65
Q

most common cause of death in MM

A

infection (decreased Ag diversity)

66
Q

M spike without MM symptoms

A

MGUS
(monoclonal gammopathy of undetermined significance)

67
Q

waldenstrom macroglobinemia

A

IgM M spike
serum hyperviscocity
bleeding

68
Q

eosinophilic granuloma

A

pathologic fracture

69
Q

letterer-siwe disease

A

rash and skeletal defects in children
langerhans cell malignancy

Pathoma (12 decks)

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