WBC

Question 1

CD34+

Answer 1

hematopoietic stem cell

Question 2

CD16

Answer 2

Fc receptor

Question 3

GM-CSF/G-CSF boost ___ numbers

Answer 3

neutrophil

Question 4

most sensitive cell to radiation

Answer 4

lymphocyte

Question 5

left shift characterized by decreased ___ ___ on immature neutrophils

Answer 5

Fc receptors (CD16)

Question 6

high cortisol state increases ___ count

Answer 6

neutrophil (due to demargination)

Question 7

eosinophilia increased in ___ lymphoma

Answer 7

hodgkin (due to IL-5)

Question 8

basophilia increased in ___ (leukemia)

Answer 8

CML

Question 9

___ ___ (bacteria) produce lymphocytosis

exception

Answer 9

b pertussis

Question 10

lymphadenopathy due to hyperplasia of the ___

Answer 10

paracortex

Question 11

splenomegaly due to hyperplasia of the ___ ___ ___

Answer 11

periarterial lymphatic sheath

Question 12

what is the cell of infectious mononucleosis

Answer 12

CD8+ (atypical lymphocytes)

Question 13

monospot test detects Ig___ antibodies

Answer 13

IgM

Question 14

do not give ___ to patients with mono

Answer 14

ampicillin (rash)

Question 15

EBV remains dormant in ___ cells

Answer 15

B

Question 16

> 20% blast cells

Answer 16

acute leukemia
(1-2% WNL)

Question 17

how does acute leukemia present? (3)

Answer 17

anemia
thrombocytopenia
neutropenia

Question 18

ALL stains positive for ___

Answer 18

TdT (DNA polymerase)

Question 19

ALL associated with ___

Answer 19

DS

Question 20

AML blasts contain ___, which appears as an ___ ___(s)

Answer 20

MPO
auer rod

Question 21

T-ALL contain the markers between CD_ - CD_

Answer 21

CD2 - CD8

Question 22

t(12,21)

Answer 22

ALL

Question 23

t(9,22) can be seen in which leukemias

Answer 23

ALL (severe)
CML (most common)

Question 24

ALL requires prophylaxis to ___ and ___

Answer 24

scrotum
CSF

Question 25

t(15,17)

Answer 25

APL (retinoic acid receptor disrupted)

Question 26

APL Tx

Answer 26

all-trans retinoic acid

Question 27

auer rods increase risk for ___

Answer 27

DIC

Question 28

acute monocytic leukemia presentation

Answer 28

gingival abnormality

Question 29

acute megakaryoblastic leukemia associated with ___

Answer 29

DS

Question 30

CLL co-expresses CD_ and CD_

Answer 30

CD5 CD20

Question 31

hairy cell leukemia positive for ___

Answer 31

TRAP

Question 32

hairy cell leukemia Tx

Answer 32

cladribine (adenosine deaminase inhibitor)

Question 33

___ is associated with HTLV-1

Answer 33

ATLL

Question 34

mycosis fungoides

Answer 34

neoplastic proliferation of CD4+ within the epidermis

Question 35

BCR-ABL fusion protein relevance

Answer 35

increased TK activity

Question 36

polycythemia vera associated with what mutation?

Answer 36

JAK2 kinase

Question 37

CML Tx

Answer 37

imatinib (TK inhibitor)

Question 38

CML is LAP ____

Answer 38

negative

Question 39

what can cause itching after bathing?

Answer 39

polycythemia vera

Question 40

essential thrombocythemia associated with what mutation?

Answer 40

JAK2 kinase

Question 41

myelofibrosis can present with what on blood smear?

Answer 41

dacrocytes (tear-shaped)

Question 42

myelofibrosis associated with what mutation?

Answer 42

JAK2 kinase

Question 43

CD18 mutation in ___

Answer 43

LAD

Question 44

follicular hyperplasia seen in ___ and early ___

Answer 44

RA HIV

Question 45

paracortex hyperplasia seen in ___ ___

Answer 45

infectious mono

Question 46

t(14,18)

Answer 46

follicular lymphoma excess Bcl2

Question 47

t(11,14)

Answer 47

mantle cell lymphoma excess cyclin D

Question 48

t(14,18) Tx

Answer 48

rituximab (anti-CD20)

Question 49

t(14,18) can progress to what?

Answer 49

diffuse large b-cell lymphoma

Question 50

follicular hyperplasia vs lymphoma

Answer 50

follicular invasion NO tingible body macrophages Bcl2 expression

Question 51

cyclin D function

Answer 51

G1 > S progression

Question 52

what lymphoma is associated with chronic inflammation

Answer 52

marginal zone (hashimoto, SS, h pylori)

Question 53

"starry sky" appearance

Answer 53

burkitt lymphoma t(8,14)

Question 54

t(8,14)

Answer 54

burkitt lymphoma c-myc expression

Question 55

sporadic burkitt lymphoma appears where in the body?

Answer 55

abdomen (vs African in mandible)

Question 56

reed-sternberg cells

Answer 56

hodgkin lymphoma

Question 57

hodgkin lymphoma is CD_ and CD_ positive

Answer 57

CD15 CD30

Question 58

most common HL

Answer 58

nodular sclerosis (hard nodules separated by fibrosis)

Question 59

IL-_ is elevated in MM

Answer 59

IL-6

Question 60

IL-_ is elevated in AS

Answer 60

17

Question 61

"punched-out" lytic lesions

Answer 61

MM

Question 62

M spike denotes what?

Answer 62

monoclonal Ig (common in MM)

Question 63

rouleaux formation on blood smear

Answer 63

MM

Question 64

amyloid in MM

Answer 64

AL (light chain)

Question 65

most common cause of death in MM

Answer 65

infection (decreased Ag diversity)

Question 66

M spike without MM symptoms

Answer 66

MGUS (monoclonal gammopathy of undetermined significance)

Question 67

waldenstrom macroglobinemia

Answer 67

IgM M spike serum hyperviscocity bleeding

Question 68

eosinophilic granuloma

Answer 68

pathologic fracture

Question 69

letterer-siwe disease

Answer 69

rash and skeletal defects in children langerhans cell malignancy