Warfarin Flashcards
1
Q
What is it indicated?
A
VTE
AF
To prevent arterial embolism from mechanical heart valves
2
Q
How do they work?
A
It inhibits vitamin K epoxide reductase reducing production of vitamin K dependent clotting factors
3
Q
What are the side effects of this drug?
A
Bleeding
4
Q
What drug reverses the effect of bleeding?
A
phytomenadione (vitamin K1)
5
Q
What are the warnings for this drug?
A
Active bleeding
Liver disease
Pregnancy first trimester
6
Q
What drugs interact with warfarin?
A
CYP inducers, phenytoin, carbamazepine, rifampicin) increase warfarin metabolism and risk of clots.
CYP inhibitors (e.g. fluconazole, macrolides) decrease warfarin metabolism and increase bleeding risk
