Fibrinolytic drugs Flashcards
1
Q
What are they indicated for?
A
Acute ischaemic stroke
ST-elevation acute coronary syndrome
Massive PE
2
Q
What is the mechanism of action of these drugs?
A
Catalyse the conversion of plasminogen to plasmin
3
Q
What are the side effects of these drugs?
A
Nausea
Vomiting
Bruising
Hypotension
4
Q
What adverse effects can occur which require these drugs to be stopped?
A
serious bleeding
allergic reaction
cardiogenic shock
Cardiac arrest
5
Q
What are the warnings for this drug class?
A
Contraindicated in bleeding
Previous streptokinase treatment
6
Q
What drugs interact with this class?
A
Anticoagulants and antiplatelets- bleeding
ACEi increase risk of anaphylactoid reactions
7
Q
What drugs are in this class?
A
Alteplase
Streptokinase
