Adenosine

Question 1

What is it used for?

Answer 1

Supraventricular tachycardia (SVT) without life threatening features.

Question 2

How does it work?

Answer 2

It works by binding to adenosine receptors on cell surfaces. Thereby slowing sinus rate.

Question 3

What are the contraindications for the drug?

Answer 3

Hypotension
Coronary ischaemia
Decompensated heart failure
Asthma
COPD
Heart transplant patients

Question 4

What are the cautions of this drug?

Answer 4

AF
Atrial flutter
Recent MI

Question 5

What are the side effects of this med?

Answer 5

It can induce bradycardia
Breathlessness
hypotension (discontinue if severe)
Chest pain (discontinue)

Question 6

What other agents does it interact with?

Answer 6

Dipyridamole- antiplatelet blocks cellular uptake of adenosine. Prolonging its effect therefore adenosine dose should be halved.

Theophylline and aminophylline are competitive antagonist of adenosine receptors and reduce its effect

Question 7

What are the monitoring requirements of adenosine?

Answer 7

It needs to be closely monitored and this must include a continuous cardiac rhythm strip, recorded for subsequent inspection.

Question 8

Can it be used in pregnancy?

Answer 8

Large doses may produce fetal toxicity; manufacturer advises use only if potential benefit outweighs risk.