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Cardiovascular disease medicines > Thiazide and Thiazide-like diuretics > Flashcards

Thiazide and Thiazide-like diuretics Flashcards

1
Q

What is it indicated for?

A

Hypertension
Oedema

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2
Q

What is the mechanism of action?

A

They inhibit the Na+/Cl− co-transporter in the distal convoluted tubule of the nephron.

Preventing sodium reabsorption and its osmotically associated water

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3
Q

What are the side effects of these drugs?

A

Hyponatraemia
Hypokalaemia- causing cardiac arrhythmias
Impotence in men
May increase plasma concentrations of glucose, LDL and triglycerides

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4
Q

What are the warnings of this drug class?

A

Hyponatraemia
Hypokalaemia
Gout- as they reduce uric acid excretion precipitating an acute attack

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5
Q

What drugs do they interact with?

A

NSAIDs (not low dose aspirin though)- reduced effectiveness of diuretic
Drugs that lower potassium concentration

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Cardiovascular disease medicines (20 decks)

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