Statins Flashcards
1
Q
What is indicated for?
A
Primary or secondary prevention of major adverse cardiovascular events
Dyslipidaemia
2
Q
How do they work?
A
Inhibit HMG CoA reductase thereby lowering cholesterol production
3
Q
What are some of the side effects of these drugs?
A
Headache
GI upset
Muscle aches
Increased liver enzymes
myopathy
Rhabdomyolysis
4
Q
What are the warnings of these drugs?
A
Hepatic impairment
Renal impairment (except rosuvastatin)
They are contraindicated in pregnancy and should be avoided in breastfeeding
5
Q
What drugs do they interact with?
A
Cytochrome P450 inhibitors like amiodarone, diltiazem, itraconazole, macrolides, protease inhibitors and grapefruit juice (other than rosuvastatin)- They cause accumulate statin
