WAFARIN Flashcards
What is the main use of anticoagulants?
- To prevent thrombus formation or extension of an existing thrombus in the slower-moving venous side of the circulation
- The slower-moving venous side of the circulation has thrombus consisting of a fibrin web enmeshed with platelets and red cells
Examples of oral AC
- Warfarin Sodium
- Acenocoumarol
- Phenindione
They all antagonise the effect of vitamin K
How long does it take for the anticoagulant effect to fully develop?
48-72 hours
Which oral anticoagulant is the drug of choice?
Warfarin Sodium
What should be determined at baseline? Does this affect the initial dose of Warfarin?
- The base-line prothrombin time should be determined
- BUT the initial dose SHOULD NOT be delayed whilst awaiting the result
If INR is within 0.5 units of the target value…
This is generally satisfactory
Any larger deviations require dose adjustments
Warfarin - maintain INR of 2.5
- VTE
- AF
- Cardioversion
- MI
- Cardiomyopathy
Warfarin -Maintain INR of 3.5
Recurrent VTEs or mechanical heart valves
How long should warfarin be taken for treatment of DVT/ PE?
- 6 weeks for isolated calf-vein DVT
- 3 months - VTE provoked by surgery
- At least 3 months - unprovoked proximal DVT or PE
Main adverse effect
Bleeding (haemorrhage)
Antidote to bleeding
Phytomenadione (VK agonist)
Major bleed
- Stop warfarin
- IV phytomenadione +
- dried prothrombin complex
INR >8, minor bleeding:
- Stop warfarin
- IV phytomenadione
- Repeat doses of phyto if INR is still too high after 24hrs
- Restart wafarin when INR is < 5
INR >8, no bleeding:
- Stop warfarin
- PO phytomenadione
- Repeat doses of phyto if INR is still too high after 24hrs
- Restart wafarin when INR is < 5