WAFARIN Flashcards

1
Q

What is the main use of anticoagulants?

A
  • To prevent thrombus formation or extension of an existing thrombus in the slower-moving venous side of the circulation
  • The slower-moving venous side of the circulation has thrombus consisting of a fibrin web enmeshed with platelets and red cells
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2
Q

Examples of oral AC

A
  • Warfarin Sodium
  • Acenocoumarol
  • Phenindione
    They all antagonise the effect of vitamin K
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3
Q

How long does it take for the anticoagulant effect to fully develop?

A

48-72 hours

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4
Q

Which oral anticoagulant is the drug of choice?

A

Warfarin Sodium

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5
Q

What should be determined at baseline? Does this affect the initial dose of Warfarin?

A
  • The base-line prothrombin time should be determined
  • BUT the initial dose SHOULD NOT be delayed whilst awaiting the result
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6
Q

If INR is within 0.5 units of the target value…

A

This is generally satisfactory
Any larger deviations require dose adjustments

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7
Q

Warfarin - maintain INR of 2.5

A
  • VTE
  • AF
  • Cardioversion
  • MI
  • Cardiomyopathy
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8
Q

Warfarin -Maintain INR of 3.5

A

Recurrent VTEs or mechanical heart valves

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9
Q

How long should warfarin be taken for treatment of DVT/ PE?

A
  1. 6 weeks for isolated calf-vein DVT
  2. 3 months - VTE provoked by surgery
  3. At least 3 months - unprovoked proximal DVT or PE
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10
Q

Main adverse effect

A

Bleeding (haemorrhage)

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11
Q

Antidote to bleeding

A

Phytomenadione (VK agonist)

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12
Q

Major bleed

A
  1. Stop warfarin
  2. IV phytomenadione +
  3. dried prothrombin complex
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13
Q

INR >8, minor bleeding:

A
  1. Stop warfarin
  2. IV phytomenadione
  3. Repeat doses of phyto if INR is still too high after 24hrs
  4. Restart wafarin when INR is < 5
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14
Q

INR >8, no bleeding:

A
  1. Stop warfarin
  2. PO phytomenadione
  3. Repeat doses of phyto if INR is still too high after 24hrs
  4. Restart wafarin when INR is < 5
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15
Q
A
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16
Q

INR 5-8, minor bleeding

A

Stop warfarin - IV phytomenadione

17
Q

INR 5-8, no bleeding:

A

Withhold 1-2 doses of warfarin

18
Q

When should you restart warfarin?

A

Restart warfarin when INR <5

19
Q

How often should INR be monitored?

A

INR should be monitored every 1-2 days in early treatment, and then every 12 weeks

20
Q

Warfarin - surgery where there is a risk of severe bleeding:

A
  • Stop warfarin 3-5 days before
  • Give phyto if INR is >1.5 the day before surgery
21
Q

High risk of VTE when undergoing surgery

A

bridge with LMWH → stop LMWH 24 hours before surgery → restart LMWH 48 hours after

22
Q

Warfarin - emergency Surgery

A
  • If can be delayed by 6-12 hours: IV Vitamin K
  • If can’t be delayed by 6-12 hours: IV Vitamin K + dried prothrombin complex
23
Q

Which antiplatelet has a higher risk of bleeding in combo with warfarin?

A

Clopidogrel
- aspirin + warfarin have risk of bleeding, but it’s lower

24
Q

Warfarin - side effects

A

MHRA Warning: SKIN NECROSIS AND CALCIPHYLAXIS
- Painful skin rash
Haemorrhage: Prolonged Bleeding
- Vitamin K1 (phytomenadione) antidote

25
Q

CI

A
  • AVOID use within 48 hours post-partum (giving birth)
  • Haemorrhagic stroke
  • Significant bleeding
  • pregnancy
26
Q

Can Vitamin K
antagonist be used in pregnancy?

A
  • AVOID in pregnancy
  • Warfarin, acenocoumarol and phenindione cross the placenta with a risk of congenital malformations, and placental, fetal or neonatal haemorrhage
27
Q

What is the dose of warfarin?

A

Initially:
- 5-10mg daily on day 1
- Subsequent doses depend on prothrombin time
- a lower dose may be given to those who do not require rapid anticoagulation
- Elderly require a lower induction dose

28
Q

How often to
administer warfarin?

A
  • once a day in the evening
  • same time of the day
  • preferably on an empty stomach
29
Q

What happens if you forget a dose of warfarin?

A
  • do NOT double up!
  • take it as soon as you remember and let the clinic team know!
30
Q

Interactions

A
  • Amiodarone - increases plasma concentration
  • Azathioprine reduces the anticoagulant effect
  • Antifungals (Azoles e.g.
    Miconazole) increases anticoagulant effect
  • Carbamazepine reduces plasma concentration
  • Corticosteroids may induce or enhance the anticoagulant effect
  • Metronidazole increases anticoagulant effect
  • NSAIDs may enhance the anticoagulant effect
  • Phenytoin reduces the anticoagulant effect
  • Rifampacin decreases anticoagulant effect
  • Statins (Fluvastatin,
    Rosuvastatin) increases the anticoagulant effect of warfarin
31
Q

What’s the easiest way to determine interaction with warfarin with regards to cytochrome enzymes?

A

Warfarin is metabolised by Cytochrome P450 enzymes, so any enzyme inducers/ inhibitors will affect its metabolism & thus INR, so the dose may need to be adjusted

32
Q

Warfarin diet & alcohol interactions

A
  • Alcohol (in those who drink heavily) can potentially decrease the anticoagulant
    effect of coumarins
  • Pomegranate can increase
    INR in warfarin and acenocoumarol
  • Cranberry juice can increase the anticoagulant effect of warfarin
  • Avoid large amounts of green vegetables and green tea
33
Q

Which fruits should you avoid whilst on warfarin?

A
  • grapefruit juice
  • cranberry juices
  • Pomegranate
  • mango juices
  • mangoes
  • Seville oranges
34
Q

Which anticoagulant discolours urine pink or orange?

A

Phenindione