VTE Flashcards

1
Q

Types of VTE

A

DVT
PE
- due to blood clot which forms in the veins - restricts blood flow

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2
Q

RF

A

Surgery
Trauma
Significant immobility
Malignancy
Obesity
Pregnancy
Hormonal Therapy (COC or HRT)

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3
Q

DVT

A
  • Blood clot occurs in a deep vein leg or pelvis
  • Typically in the calf of one leg.
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4
Q

Symptoms of DVT

A
  • unilateral, localised pain
  • swelling/ tenderness
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5
Q

Wells score for DVT

A
  • 2 + = DVT likely
  • less than 2 = unlikely
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6
Q

2 + wells score for DVT

A
  • Offer a proximal leg vein ultrasound scan
  • If the scan is negative for
    DVT, then offer a D-Dimer test
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7
Q

Less than 2 wells score for DVT

A
  • Offer first a D-Dimer test
  • If the D-Dimer test confirms that DVT is likely, then offer a proximal leg ultrasound scan
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8
Q

PE

A

Blood clot detaches and travels to the lungs and blocks the pulmonary artery.

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9
Q

Symptoms of PE

A
  • Chest pain
  • Shortness of breath
  • Cough
  • Coughing blood (Haemoptysis)
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10
Q

Wells score for PE

A
  • 4 + = PE likely
  • less than 4 = unlikely
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11
Q

4 + wells score for PE

A
  • computed tomography pulmonary angiogram (CTPA)
  • if PE is negative, consider proximal leg ultrasound if DVT is suspected/likely
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12
Q

Less than 4 wells score for PE

A
  • D-dimer test
  • if positive = CTPA
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13
Q

Methods of thromboprophylaxis (2)

A
  1. Mechanical - graduated compression stockings
  2. Pharmacological - anticoagulants
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14
Q

How would you reduce risk of VTE in surgical patients?

A
  • LA over GA
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15
Q

In surgical pt - how long is mechanical prophylaxis for VTE sufficient

A
  • until sufficiently mobile
  • discharged from hospital, some surgeries require them to be worn for certain amount of days
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16
Q

Surgery - how long do we continue VTE prophylaxis for?

A
  • Continue for at least 7 days post-surgery, or until sufficient mobility has been re-established
  • 28 days after major cancer surgery in the abdomen
  • 30 days in spinal surgery
17
Q

Elective hip replacement either

A

LMWH for 10 days and then 75mg aspirin for 28 days
LMWH for 28 days in + stockings until discharge
Rivaroxaban

18
Q

Elective knee replacement either:

A

75mg aspirin for 14 days
LMWH for 14 days in + stockings until discharge
Rivaroxaban

19
Q

VTE prophylaxis - Pregnancy high risk of VTE

A
  • If risk of VTE that outweighs the risk of bleeding
  • LMWH during hospital admission
  • Pregnant women: prophylaxis until no risk of VTE or till patient discharged
20
Q

Women who have given birth, had a miscarriage or termination of pregnancy during the past 6 weeks →

A

start LMWH 4-8 hours after the event → continue for a minimum of 7 days

unfractionated if patient is at high risk of haemorrhage

21
Q

Pregnancy - Additional mechanical prophylaxis if immobilised →

A

until sufficiently mobile or discharged from hospital

22
Q

Why are Heparins used in pregnancy compared to other pharmacological prophylaxis?

A
  • Heparins do NOT cross the placenta
  • They are also cleared rapidly in pregnancy
23
Q

If a patient has confirmed DVT or PE, What should you offer for treatment?

A
  • Apixaban
    OR
  • Rivaroxaban
24
Q

What if Apixaban or
Rivaroxaban are unsuitable for a patient with VTE, what should you then offer as an alternative?

A
  1. LMWH for at least 5 days followed by Dabigatran or Edoxaban
  2. LMWH + warfarin for at least 5 days or until the INR is at least 2.0 or above
  3. Stop heparin and continue on warfarin on its own
25
Q

When would Heparin (unfractionated) be recommended in the treatment of VTE?

A
  • Not routinely recommended
  • only considered in patients with renal impairment
26
Q

How long should patients be on drug treatment for VTE?

A
  • Distal DVT (calf): 6 Weeks
  • Proximal DVT / PE: At least 3 months (3 to 6 months for those with active cancer)
  • Provoked DVT / PE: Stop at 3 months if the provoking factor resolved
  • Unprovoked DVT / PE: 3 Months +
  • Recurrent DVT / PE: Longterm
27
Q

Review

A

anually