DOACs + HEPARINS

Question 1

Apixaban

Answer 1

Apixaban: 10mg BD for 7 days → 5mg BD

Question 2

Rivaroxaban

Answer 2

15mg BD for 3 weeks → 20mg OD
Should be taken with food

Question 3

DOACs for TREATMENT of TE

Answer 3

newer gen of ACs which require no monitoring
Apixaban Dabigatran Edoxaban Rivaroxaban

Question 4

Dabigatran

Answer 4

150mg BD aged 18-74, 110-150 BD aged 75-79, 110mg BD aged 80+

Question 5

Edoxaban

Answer 5

60mg OD, 30mg OD if patient weighs under 61kg

Question 6

LMWH with DOAC

Answer 6

dabi and edox start once pt has had 5 days of LMWH

Question 7

All Heparins

Answer 7

Avoid in heparin-induced thrombocytopenia
Can cause hyperkalaemia
Haemorrhage - treat with PROTAMINE SULPHATE (used for unfractionated heparin)

Question 8

Heparin (unfractionated)

Answer 8

Quick initiation and elimination - ideal in high bleeding risk (Monitor APTT)
Higher risk of heparin-induced thrombocytopenia than LMWH
* Preferred in renal impairment

Question 9

Low Molecular Weight Heparin

Answer 9

Preferred in pregnancy
Unauthorised recording and reproduction of this lecture will result