DRONEDARONE Flashcards
1
Q
Indication
A
- Maintenance of sinus rhythm after cardioversion in clinically
stable patients with paroxysmal or persistent AF, when alternative treatments are unsuitable - initiated under specialist supervision
2
Q
A
3
Q
CI
A
- HF
- Lung toxicity (interstitial lung disease, pneumonitis, pulmonary fibrosis)
- QT
4
Q
SE
A
- Heart tailure (if occurs discontinue)
- Bradycardia
- pulmonary toxicity
- Long QT syndrome
- Hepatoxicity
5
Q
How would you know if liver injury is occurring with dronedarone?
What must you do if it is occurring?
A
- AAT conc would exceed 3 x UL
- abdominal pain, anorexia, N&V, fever, dark urine, jaundice
- STOP
6
Q
How would you know if pulmonary toxicity is occurring with dronedarone? What must you do?
A
- symptoms such as dyspnoea
(SOB) and dry cough - Discontinue if it occurs
7
Q
What are the symptoms of HF that patients need to be warned about with dronedarone?
A
- Weight gain
- Oedema
- dysponea
8
Q
What are the monitoring requirements for dronedarone?
A
- Monitor for HF
- ECG every 6 months
- Serum creatinine 7 days before and after initiation
- Liver function
