ANTIHYPERTENSIVE DRUGS Flashcards
ACEI - examples
Ramipril Enalapril Lisinopril Perindopril
ACEi - side effects
Cough (give ARB instead)
Hyperkalaemia
Hepatic Failure
Angioedema
Renal Impairment
Dizziness and Headaches
CHHAReD
ACEi - interactions
Increase Risk of Renal Failure
- ARBs, K-Sparing Diuretics, NSAIDs
Increase Hyperkalaemia
- Heparins, ARBs, NSAIDs, K-Sparing Diuretics, Beta-Blockers
Increase Risk of Volume Depletion
- Diuretics
Increase plasma levels of
- Lithium
Angiotensin-Il Receptor Blockers (ARBS) - example
Candesartan Irbesartan Losartan
ARB - side effects
Same side-effects and interactions as ACE-l, apart from cough and angioedema
Beta blockers - examples
Atenolol Bisoprolol Carvedilol Labetalol Propranolol Sotalol Timolol
Cardio Selective B-blockers
Less likely to cause bronchospasms
Bisoprolol
Atenolol
Metoprolol
Acebutolol
Nebivolol
BAtMAN
Water Soluble B-blockers
Less likely to cross BBB → Less nightmares
Celiprolol Atenolol Nadolol Sotalol
Water CANS
Intrinsic Sympathomimetic B-Blockers
Less likely to cause cold extremities
Pindolol Acebutolol Celiprolol Oxprenolo!
Ice PACO
Which beta blocker would you give to an asthmatic
Cardio Selective B-blockers
less likely to cause bronchospasms
BB - side effects
Bradycardia or heart failure
Blunt the effects of hypoglycaemia
> Can cause hyperglycaemia
Bronchospasms → Contraindicated in asthmatic patients
BB - interactions
Digoxin: Cause heart block
Any other hypotensive drug
Calcium-Channel Blockers (CCB) - examples
Dihydropyridine: Amlodipine Felodipine Lacidipine Lercanidipine Nifedipine
Rate-limiting: Diltiazem Verapamil
CCB - side effects
Dizziness
Gingival Hyperplasia
Vasodilatory effects (flushing, headaches, ankle swelling): More in Dihydropyridines
Complete Atrioventricular Block: More in Rate-Limiting
