W5 - Salivary Gland Disorders - Thomson Flashcards
What are the 4 salivary glands
- Parotid
- Submandibular
- Sublingual
- Minor salivary glands
What type of saliva does the parotid, submandibular and sublingual glands produce, respectively?
Parotid - Serous
Submd - Mixed (10% mucinous)
Subling - Mixed (10% serous)
Where does the majority of saliva come from? (glands)
Submandibular (75%)
Parotid (25%)
Sublingual (5%)
Problems that salivary hypofunction / xerostomia cause (5)
Difficulty chewing and swallowing
Erythematous & atrophic oral mucosa
Lobulation & depapillation of tongue
Caries
Oral candidiasis / angular cheilitis
Primary causes of xerostomia (salivary gland pathology) (6)
Aplasia (missing gland) Excision / irradiation Infection / obstruction Sjogrens HIV Cystic Fibrosis
Secondary causes of xerostomia (4)
Anxiety
Neurological
Drug therapy
Fluid / electrolyte imbalance
What type of drugs cause xerostomia? (5)
antihistamines
antidepressants
antipsychotics
anti-cholinergics
diuretics
How can salivary gland diseases be classified (2)
Neoplastic
non neoplastic
Reasons for non-neoplastic salivary gland disease (7)
Developmental Obstructive Inflammation Ischaemic Trauma Infection Autoimmune
4 classifications of salivary disease clinical presentation + examples
- Acute inflammatory swellings (acute sialadenitis)
- Recurrent swellings (sialolith)
- Persistent diffuse enlargement (sjogrens)
- Nodular enlargement (neoplasm, cyst, lymph node)
Synonym for sialolith
Salivary calculi
4 reasons for recurrent swelling of salivary gland
- Salivary calculi
- Papillary obstruction
- Duct Stricture
- Punctate sialectasis
What is acute sialadenitis? 3 types?
Infection causing acute inflammatory swelling
- Viral (mumps)
- Suppurative
- Granulomatous
3 reasons for persistent diffuse enlargement of salivary glands
Sjogrens syndrome
Sialosis
Sarcoidosis
What is sjogrens syndrome?
Chronic multisystem autoimmune exocrinopathy
- affects middle aged / elderly females
2 types of sjogrens syndrome
Primary “Sicca syndrome” - salivary and lacrimal glands affected
Secondary - salivary/lacrimal glands, + connective tissue/autoimmune disease
- Rheumatoid arthritis, Systemic lupus erythematous
Features of sjogrens syndrome (4)
Persistent xerostomia - dry mouth, caries, depapillated tongue, etc.
Persistent xeropthalmia - dry eyes
Salivary and lacrimal gland enlargement
Parotitis - swollen parotid
Investigations / tests for sjogrens (5)
Unstimulated SFR - <1.5mL in 15 min
Sialography imaging
Labial gland biopsy
Schirmer test - tear production <5 mm / 5 min
Blood test - Rheumatoid factor, Anti-Ro, Anti-La antibodies
What is this
Sialography test for investigating sjogrens syndrome
What dangerous thing can histopathology show about sjogren syndrome?
Lymphocyte infiltration within intra-glanular septa, acinar atrophy and destruction -> risk of LYMPHOMA
Management of sjogrens syndrome
Keep in mind that salivary gland damage is irreversible -> focus on symptomatic relief
Biotene
Caries control
Management of infection and candidiasis
Regular parotid gland examination
Visits with opthamology and rheumatology
Benign vs malignant salivary gland tumour symptoms
Benign: slowly enlarging, symptomless lump
Malignant: Rapid enlargement Pain Ulceration Bone destruction Trismus Facial paralysis
Pt says this has been growing slowly. Feels no pain
Benign salivary gland tumour