W5 Cell communication&signalling/Lec8 Flashcards
Dr Nannetti Compare and discuss the types of cell communication/signalling Explain the principles and the 3 main stages of cell signalling Define the different types of receptors involved in cell transduction
What are gap/communicating junctions? (description of features)
What do gap junctions allow the exchange of?
-They consist of 2 cylindrical channels (connexons composed of 6 connexin proteins each) on the plasma membrane of adjacent cells that are joined together to form a pore.
- Allowing direct and bidirectional exchange of
molecules/ions between 2 neighbour cells - No effect in cell-ECM adhesions
What are the 3 types of junctions?
Gap junctions, anchoring junctions and tight junctions.
What are the 5 types of cell signalling?
Contact-dependent
Paracrine
Synaptic
Endocrine
Autocrine
What is contact-dependent signalling?
What does a signal molecule bind to?
How are the signals exchanged?
=Signals between interacting cells
- A signal molecule binds to a receptor on an interacting cell
Interactions between immune cells (to induce an immune response against specific microorganisms) - Signals exchange via gap junctions
What is the cell-signalling pathway?
Divided into 3 steps
1. Signal-receptor binding
2. Signal transduction
3. Specific cell response
Where are intracellular receptors found?
In the cytosol or nucleus of target cells.
What are the 3 main classes of cell-membrane receptors?
- Ion channel-coupled receptors
- G protein-coupled receptors (GPCRs)
3.Enzyme-coupled receptors
Also Cytosolic and nuclear receptors
What are Ion channel-coupled receptors?
What is an example?
Where are they found
- The receptor conformational change after binding to the signal activates an ion channel acting as a gate for specific ions, changing the intracellular charge
- Converting chemical signals into electrical ones (nerve impulse conduction)
- Nicotinic Acetylcholine Receptor
- Nerve cells and other electrically excitable cells such as muscle cells
What are G proteins-coupled receptors (GPCRs)?
- Largest class of cell-surface receptors
- G proteins-linked receptors have a common structure, with 2 components
What type of cell signalling occurs over long distances?
Endocrine system
Cell communication in which neurons release neurotransmitters to excite or inhibit the activity of other neurons or target cells?
Synaptic
What is the Cell communication between distant cells, in which the signal molecules are hormones.
(Hormones are produced by endocrine cells and travel through the blood to reach distant parts of the body)
Endocrine
What is the Cell communication with their immediate neighbour cells through a direct membrane–membrane contact?
Contact-dependent signalling
What is the Cell signalling mediated by molecules, which act on the same cells that produce them?
Autocrine
Cell signalling mediated by molecules, which act on the same cells that produce them
Autocrine