W33/L8: HIV drugs Flashcards
1
Q
What are some good targets for HIV ART?
A
Fusion/entry
RT
Integrase
Protease
2
Q
What makes the co-receptors of fusion good targets for ART?
A
We know they’re redundant, so there should be minimal ADRs
3
Q
What’s an R5 coreceptor antagonist?
A
Maraviroc
4
Q
NT vs NS - which have phosphate groups?
A
Nucleotides
5
Q
NT vs NS - which is the susbtrate for DNA?
A
It’s a nucleotide, because it’s neucleoside triphosphate
6
Q
NT vs NS - Acyclovir for herpes is a ___ analogue
A
Nucleoside analogue
7
Q
How does valacyclovir (Valtrex) relate to acyclovir?
A
It’s modified to have better bioavailability
8
Q
What sort of drug is Zidovidine (AZT)?
A
A thymidine analogue
= NsRTI
