W33/L5 Flashcards
1
Q
Where are the cell bodies of pain fibres?
A
Dorsal root ganglion
2
Q
Where do pain fibres synapse?
A
Dorsal horn of spinal cord
3
Q
What are the two main types of pain fibres?
A
A-delta
C
4
Q
What sensations are carried by the A-delta fibres?
A
Fast, sharp, acute, prickling localised pain
Mechanical & thermal
5
Q
What sensations are carried by the C fibres?
A
Slow, aching, throbbing pain
Burning & chemical
6
Q
On which receptors does glutamate primarily act?
A
AMPA & NMDA
7
Q
Which glutamate receptor has a high threshold?
A
NMDA
8
Q
What’s the key event in NMDA activation?
A
Displacement of the Mg2+ plug
9
Q
Which drug acts on the NMDA receptor?
A
Ketamine
