W33/L6 Flashcards
The word latency is used in 2 ways in HIV discussion. What are the 2 types, and what do they mean?
Clinical latency - the asymptomatic phase of HIV infection.
Virological latency - this idea that the HIV DNA integrates into our genome and remains there.
What are the 3 phases of HIV infection?
Primary infection
Asymptomatic
Symptomatic infection
What is happening in the primary/acute HIV infection stage?
Rapid & huge loss of somatic T cells
HIV load rapidly rises, then falls as the DC4 substrate is exhausted
How long is the incubation period of HIV infection?
~3 weeks
How long is the clinical illness phase of HIV infection?
1 - 4 weeks
Which serological test will be the first to demonstrate HIV infection, and when?
PCR for viral RNA
Will be possible by 20 days
What does HIV viral load refer to?
Amount of HIV RNA in the plasma
What’s the error rate of HIV replication?
1:10,000 neucleotides
What are the 5 broad methods HIV has to avoid the immune response?
Sequence variation Altered antigen presentation Loss of effector cells Latency Privileged sites of viral replication
What are two fungal opportunistic infections that can be AIDS-related?
Pneumonia with Pneumocystis jirovecii
Oral infections with candida albicans
Which latent viral infections can be re-activated in AIDS?
EBV
CMV
What are the classes of HIV antivirals? (6)
Neucleoside RT inhibitors Non-neucleoside RT inhibitors Neucleotide RT inhibitors Entry inhibitors Protease inhibitors Integrade inhibitors
