W1 MORPHOLOGY PT 3

Question 1

What is the normal marrow cellularity of an adult?

Answer 1

must be between 40 & 60% on adults

Question 2

What is marrow cellularity?

Answer 2

Proportion of haemapoietic cells in the bone marrow compared to other components making the bone marrow such as fat cells (adipocytes) and stromal cells

Question 3

Describe the marrow cellularity of children?

Answer 3

It is hypercellular. There are more hemapoietic cells in the marrow than other components making up the marrow eg fat cells and stromal cells

Question 4

Describe marrow cellularity of adults

Answer 4

It is hypocellular. There are less hemapoietic cells, and more of other components making up the marrow.

Question 5

What is the use of iron stain?

Answer 5

To access presence of Fe within cells/tissue. The stain is used to diagnose iron deficiency anaemia and other hematological disoders

Question 6

What are the features showing that an iron stain was used?

Answer 6

-Firstly, iron stain is used on marrow aspirates
- The stain will show iron stores blue on macrophages.

*Iron stores are reserves of iron on macrophages

Question 7

What does increased iron stores entail, and what does reduced iron stores entail?

Answer 7

-Increased iron stores- Indicate iron overload
-Decreased iron stroes- Iron deficiency anaemia

Question 8

A tumour growing around a bone spicule

Answer 8

Lymphoma infiltrate

*This where importance of trephines comes in. In aspirates you cannot see the tumours. U’ll misdiagnose them