W04_02 Hyperkinetic movement disorders

Question 1

definition of dystonia

Answer 1

abnormal sustained posture of a body part due to involuntary muscle activation of both agonists and antagonists

Question 2

most common genetic classes of dystonia?

Answer 2

DYTs

Question 3

name common DYT dystonias

Answer 3

DYT1 - early onset
DYT5 - DOPA responsive
DYT11 - myoclonus dystonia

Question 4

wilson’s disease is a mutation in this gene on this chromosome

Answer 4

ATP7B gene on chromosome 13

Question 5

name some symptoms of acute dystonic reaction

Answer 5

torticollis, stridor, opisthotonus, retrocollis

Question 6

which 3 kinds of drugs to give for acute dystonic reactions?

Answer 6

benztropine,
diphenhydramine
amantadine

Question 7

drug treatments for dystonia?

Answer 7

artane,
baclofen,
tetrabenazine,
l-dopa,
surgery/dbs in GPi

Question 8

drug treatments for tics?

Answer 8

clonidine,
neuroleptics,
tetrabenzine

Question 9

difference between chorea and akathisia?

Answer 9

chorea - don’t know.

akathisia - urge to move.

Question 10

slow writing distal limbs is called?

Answer 10

athetosis

Question 11

features of huntington’s?

Answer 11

slowed/hypometric saccades;
chorea progressing to parkinsonism;
silted gait