L11 CSF Dynamics and BBB Flashcards
how much does the brain weigh?
1400 g in air.
45 g intracranially
how often is the CSF turned over per day?
3x per day
which kind of cells line the ventricles?
ependymal cells.
name the two components of the BBB
blood-interstitial fluid barrier
blood-cerebrospinal fluid barrier
what causes cerebral endothelial cells to form tight junctions and no fenestrations?
astrocytic foot processes.
note: fenestrations exist in choroid plexus.
the blood-CSF barrier is formed by which structure?
choroid plexus
which kinds of ependymal cells have tight junctions?
choroidal ependymal cells have tight junctions
how does the CSF leave the ventricles?
median aperture
lateral aperture x2
total volume of CSF?
140 mL;
mostly in subarachnoid space
rate of production of CSF?
500 mL / day
two means of returning CSF to vasculature?
arachnoid granulations
along sheaths of cranial/spinal nerves into lymph system (especially olfactory tract)
name for condition when CSF movement is blocked
obstructive hydrocephalus
name for condition when CSF absorption is blocked
communicating hydrocephalus
