VTE Prevention and treatment Flashcards
1
Q
Virchow’s triad
A
Blood Flow
Blood coagulability
Vessel wall damage
2
Q
What is VTE?
A
Blood clot starting in veins of calf as DVT
May remain localised
Or may extend proximally and travel through circulation to heart and get pumped to lungs where veins are smaller so gets plugged = PE
3
Q
Consequences of DVT
A
PE Post thrombotic syndrome in LT Leg ulcers at most severe Future episodes risk CTEPH
4
Q
Hypertension associated with PE
A
CTEPH
Chronic thromboembolic pulmonary HTN
5
Q
Higher risk in who?
A
- unprovoked episode vs. causative RF or persisting (surgery)
6
Q
Post-thrombotic syndrome
A
Pain, swelling Ulceration, skin discolouration Variable severity Reduced QoL 40% DVT complications
7
Q
Causes of VTW
A
- hereditary
- acquired»»
- unprovoked»_space;
(many have hereditary and acquired)
8
Q
Major RF for VTE
A
- fracture of hip/pelvis
- hip knee replacement surgery
- major trauma
- major general surgery for malignancy
- spinal cord injury
- hospitalisation with acute medical illness
(anything tthat can happen in hospital or trauma)
9
Q
Minor RF for VTE
A
- previous
- malignancy/chemo
- pregnancy or post partum
- COCP or hormone therapy
- central venous line
- thrombophilia
- other conditions = IBD, nephrotic syndrome
10
Q
Weaker but common RF
A
- age
- travel
- obesity
- varicose veins
- diet
- smoking
- air pollution
11
Q
Why do cancer patients have increased risk
A
- cancer is prothrombotic
- immobility
- surgery and chemo
- central venous catheters
(VTE 2nd equal leading cause of death in cancer patients)
12
Q
RF for VTE in pregnancy
A
- obesity
- maternal age >35
- caesarean section (esp emergency)
13
Q
Prevention
A
Thromboprophylaxis
14
Q
NICE VTE Prevention
A
- all patients on admission assess for VTE and bleeding risk (national risk assessment tool)
- offer verbal and written info on prevention to patients and carers
- provide anti-embolism stocking with right size
- re-assess within 24 hours of admission
- if at risk offer VTE prophylaxis
- offer info on discharge
- offer extended prophylaxis
15
Q
Methods of thromboprophylaxis
A
Mechanical = stockings, intermittent pneumatic compression Pharm = UH, LMWH, fondaparinux, DOACs, aspirin