Vomiting

Question 1

What are the drugs that inhibit vomiting called?

Answer 1

Anti-emetics

Question 2

What drug class targets both the CTZ and the vomiting centre?

Answer 2

Nuekokinini-1 receptor antagonists - target NK1 receptors

Question 3

What drug class antagonizes dopamine at the CT?

Answer 3

Dopamine receptor antagonists = also promotes gastric emptying
significant die effects

Question 4

What drug class is used to treat cancer patients?

Answer 4

5HT3 antagonist: very effective action at CTZ as well as other periphery receptors

Question 5

What is used to treat motion sickness?

Answer 5

Anti-histamines = side effect is sedation

Question 6

What drug is “dirty” and acts at multiple receptors?

Answer 6

Phenothiazines: pre-anaesthetic sedative

Question 7

how do Prokinetics work as an anti-emetic?

Answer 7

normalize GIT sometimes can treat nausea if there is slowed gastric emptying etc.

Question 8

What drug class can be used as an anti-emetic but is not recommended?

Answer 8

Antispasmodics

Question 9

What are the 2 best ones to use?

Answer 9

NK1 antagonist receptors and 5HT3 antagonist