Vitamin B12 absorption

Question 1

as vit B12 is ingested, which protein is produced by salivary glands?

Answer 1

R-protein

Question 2

where is vitamin B12 released from food?

Answer 2

in stomach

Question 3

the acidic pH of the stomach causes the ??? and B12 to link which protects B12 from bacteria

Answer 3

R-protein

Question 4

B12-Rprotein leaves stomach and trypsin acts upon it to cleave off the R-protein. B12 binds to ??? factor

Answer 4

intrinsic factor

Question 5

intrinsic factor is released from ??? cells

Answer 5

parietal

Question 6

B12 (with help of intrinsic factor) is absorbed into blood stream from ileum and bound to a ??? protein –> transcobalamin II

Answer 6

transport protein

Question 7

TRUE or FALSE: if parietal cell secretion of intrinsic factor is disrupted or if antibodies present = malabsorption

Answer 7

TRUE

Question 8

lack of intrinsic factor caused by:
1. autoimmune reaction against ??? & intrinsic factor (IF) itself
2. association of pernicious anaemia & other autoimmune diseases
3. antibodies to IF are higher in those with other autoimmune diseases

Answer 8

parietal cells