Visual Pathways and Control of Eye Movements Flashcards
Where do retinal ganglion axons coming down the optic nerve synapse?
Lateral Geniculate Nucleus
Where is the lateral geniculate nucleus found?
Thalamus
What are the fibres leaving the lateral geniculate nucleus called?
Optic Radiation
Which order neurones are optic radiation and where do they terminate?
4th Order Neurones
They terminate in the primary visual cortex
What are the first, second and third order neurones in the visual pathway?
First Order – photo-receptors (rods and cones)
Second Order – bipolar cells
Third Order – retinal ganglion cells
What happens as the retinal ganglion cells enter the optic nerve, which improves the transmission of the signal?
They become myelinated
What percentage of retinal ganglion cell fibres crosses the midline at the optic chiasma?
53%
Describe the convergence and receptive field sizes of rods and cones.
Rods have high convergence and large receptive fields
Cones have low convergence and small receptive fields
Describe how the convergence of the rod system differs across different parts of the retina.
The rod system near that macula has lower convergence than in the peripheral retina
What is the benefit of having high convergence and a large receptive field?
High light sensitivity
What is the benefit of having low convergence and a small receptive field?
Fine visual acuity
Retinal ganglion cells can be described as on-centre or off-centre. What do these two terms mean?
On-centre – they are stimulated by light falling on the centre of the receptive field and inhibited by light falling on the edge of the receptive field
Off-centre – they are stimulated by light falling on the edge of the receptive field and inhibited by light falling on the centre
This is important in contrast sensitivity and enhanced edge detection
Where do the fibres that decussate at the optic chiasma originate?
The nasal part of the retina
These fibres are responsible for the temporal half of the visual field
What effect do lesions anterior to the optic chiasm have on vision?
Affects only ONE eye
What effect do lesions posterior to the optic chiasm have on vision?
Affects BOTH eyes
Right-sided lesion: left homonymous hemianopia
Left-sided lesions: right homonymous hemianopia
What is the effect of a lesion at the optic chiasm?
Bitemporal hemianopia
Which part of the brain does the upper division of the optic radiation travel through and which parts of the visual field is it responsible for?
Parietal Lobe
Responsible for the inferior visual quadrants
Which part of the brain does the lower division of the optic radiation travel through and what part of the visual field is it responsible for?
Temporal Lobe
Responsible for the superior visual quadrants
The lower division loops inferiorly and anteriorly before going posteriorly towards the primary visual cortex. What is this loop called?
Meyer’s Loop
What would be the consequence of a lesion in Meyer’s loop?
Superior homonymous quadrantopia
What would be the consequence of a lesion of the upper division of the optic radiation?
Inferior homonymous quadrantopia
What is homonymous hemianopia typically caused by?
Strokes and other cerebrovascular accidents
Where is the primary visual cortex located?
Along the Calcarine Fissure in the occipital lobe
Describe which parts of the primary visual cortex are responsible for the different fields of vision.
The macula has a disproportionate representation in the primary visual cortex
The left primary visual cortex is responsible for the right visual field from both eyes
The right primary visual cortex is responsible for the left visual field from both eyes
Visual cortex above the calcarine fissure is responsible for the inferior visual field
Visual cortex below the calcarine fissure is responsible for the superior visual field
How is it possible for the macula to be spared by a stroke in the primary visual cortex leading to homonymous hemianopia?
The area representing the macula in the primary visual cortex has adual blood supply (from both right and left posterior cerebral arteries) meaning that it is less vulnerable to ischaemia
What are the two pathways of the extrastriate cortex and what are they responsible for?
Dorsal Pathway – deals with motion detection
Ventral Pathway – handles detailed object recognition and face recognition
Describe what happens to the eyes in the light.
Iric circular muscle contracts
Constriction of pupillary aperture
Reduced rate of photopigment bleaching
Increased depth of field
Describe the pathway that is responsible for the consensual lightreflex.
Retinal ganglion cells from the retina send they axons back via the optic nerve
The fibres that are responsible for the pupillary reflex will get passed the optic chiasm and then leave the posterior 1/3 of the optic tract before it reaches the LGN
The axons then go to the pretectal nucleus in the dorsal brainstem
The afferent pathways from each eye then synapse on the Edinger-Westphal nuclei on both sides of the brainstem.
A parasympathetic nerve from the Edinger-Westphal nuclei to the ciliary ganglion forms the efferent pathway Short ciliary nerves travel from the ciliary ganglion to the pupillary sphincter
Summary:
Retinal Ganglion Cell –> Pretectal Nucleus –> Edinger-Westphal Nucleus –> Ciliary Ganglion –> Short Ciliary Nerves –> Sphincter Pupillae
What would the consequences be of a right afferent defect?
Light shone in right eye: no direct or consensual response
Light shone in left eye: direct and consensual response present
What would the consequences be of a right efferent defect?
Light shone in right eye: no direct response, consensual response present
Light shone in left eye: direct response, no consensual response
What does RAPD mean?
Relative Afferent Pupillary Defect
A partial pupillary response is still present despite damage to an eye and its pupillary reflex pathway – there is some degree of constriction
What test would you do to identify RAPD? What would you expect to see in a patient showing a RAPD?
Swinging Torch Test
When the light is shone on the good eye, there will be a direct and consensual response
When the light is then swung and shone at the bad eye, there will be a paradoxical dilation of the iris in the bad eye
This is because the constriction response elicited by the bad eye is weaker than the consensual response elicited by the good eyes
Define:
a. Duction
b. Version
c. Vergeance
d. Convergeance
a. Duction Movement of one eye b. Version Simultaneous movement of both eyes c. Vergeance Simultaneous movement of both eyes in opposite directions d. Convergeance Simultaneous adduction of both eyes when viewing a near object
What is the term for the elevation of one eye?
Supraduction
What is the term for the depression of both eyes?
Infraversion
What is the technical term for right gaze?
Dextroversion
What is the technical term for left gaze?
Levoversion
What are the two types of eye movement and how are they different?
Saccade – short fast burst
Smooth Pursuit – sustained slow movement
What reflex is used to assess visual acuity in preverbal children?
Optokinetic Nystagmus Reflex
It is a form of physiological nystagmus triggered by the presentation of a constantly moving grating pattern
State which nerve innervates each of the extrinsic eye muscles.
Lateral Rectus = Abducens (CN VI)
Superior Oblique = Trochlear (CN IV)
Superior rectus and lid elevator (CN III sup)
Inferior rectus, medial rectus, inferior oblique and parasympathetic nerve for pupil constriction = CNIII inf
Where do all the rectus muscles originate?
Common tendinous ring at the apex of the orbit
Where do the rectus muscles insert?
Into the sclera anterior to the globe equator
In what position would the eye have to be to get maximum elevation/depression due to:
a. Superior and Inferior Recti
b. Superior and Inferior Obliques
a. Superior and Inferior Recti
Abducted
b. Superior and Inferior Obliques
Adducted
How would you test the extraocular muscles?
Isolate the muscle to be tested by maximising its action and minimising the action of the other muscles
E.g. to test the superior rectus, make the patient abduct and elevate their eye
Describe and explain what you would see in a patient with 3rd nerve palsy.
Their affected eye would point down and out
This is because of the unopposed contraction of lateral rectus and superior oblique
Ptosis – because of the loss of innervation of levator palpebrae superioris
Pupil dilation – loss of parasympathetic innervation to the eye via CN III
Describe and explain what you would see in a patient with 6thnerve palsy.
When asked the abduct the affected eye, they eye will stop around midline
This is because the lateral rectus isn’t functioning and can’t abduct the eye
This can lead to blurred vision
What is the extra striate cortex?
Area around visual cortex within occipital lobe responsible for converting basic visual, orientation and positional info into complex info
What are 6 extraocular eye muscles?
Superior rectus Inferior rectus Lateral (external) rectus Medial rectus Superior oblique Inferior oblique
Role of superior rectus
Moves eye up
Role of inferior rectus
Moves eye down
Role of lateral rectus
Moves eye towards temple
Role of medial rectus
Moves eye towards middle of head
Role of superior oblique
Moves eye diagonally downwards and in
Anatomical features of superior oblique
Attaches high and laterally on eye
Passes under superior rectus
Travels through trochlea
Role of inferior oblique
Moves eye diagonally up
Anatomical features of inferior oblique
Attaches low on nasal side of eye
Passes over inferior rectus
First order neurones in visual pathways
Rod and cone retinal photoreceptors
Second order neurones in visual pathway
Retinal bipolar cells
Third order neurones visual pathway
Retinal ganglion cells
What is the receptive field of a neuron
Retinal space within which incoming light can alter the firing pattern of a neuron
Difference in rod and cone system convergence
Rod system is greater than cone
Difference in convergence between centre and periphery of eye
Higher peripheral convergence
What does high convergence mean
Many photoreceptors per ganglion cell
Differences between high and low convergence
High convergence means:
Larger receptive field
Broad visual acuity
High light sensitivity
Difference in distribution of rod and cone receptors
In periphery more rod cells so better for processing fine movement
Benefit of having on and off centre ganglion cells
Contrast sensitivity
Edge detection
Common cause of bitemporal hemianopia
Pituitary gland tumour
Location of primary visual cortex
Along culcarine sulcus in occipital lobe
Other name for primary visual cortex
Striate cortex
How is the cortex characterised
Distinct stripe of myelinated optic radiation projection into cortex
Representation of visual field in cortex
Macula on lateral side of brain in very large area
Superior below culcarine fissure
Route of visual ventral pathway
Primary visual cortex to inferiotemporal cortex
Dorsal pathway visual cortex
Primary visual cortex to posterior parietal cortex
Role of extrastriate cortex
These are areas around primary visual cortex in occipital lobe
Important in converting basic visual information to complex information
Nerve supplying lid elevator
Superior branch of CN3
Supply of superior rectus
Superior branch of CN3
Supply of inferior and medial rectus
Inferior branch of CN3
Supply of inferior oblique
Inferior branch of CN3
Parasympathetic supply to constrict pupil
Inferior branch of CN3
Supply of superior oblique
CN4
Suplly of lateral rectus
CN6
Nystagmus definition
Oscillatory eye movement
Optokinetic nystagmus
Fast phase reset saccade
Optokinetic nustagmus reflex use
Used in pre- verbal children to test their visual activity
WhT is the Optokinetic nustagmus reflex
Observes presence of nystagmus movement in response to moving grating patterns
