Viruses of the hematopoietic system

Question 1

Colorodo Tick Fever Virus Envelope and Genome

Answer 1

No, and dsRNA

Question 2

Colorodo Tick Fever Virus Tropism

Answer 2

proerythrocytes and mature RBCs

Question 3

Colorodo Tick Fever Virus Pathologies and tx.

Answer 3

Sadleback fever pattern, tick resevoir Supportive,

Question 4

Cytomegalovirus Family and Genome

Answer 4

Herpes HHV-5 and dsDNA

Question 5

Cytomegalovirus Tropism

Answer 5

Systemic, latent in CD34+ cells (monocyte to macrophages)

Question 6

Cytomegalovirus pathology and Tx.

Answer 6

CMV infectious mononucleosis. Owl’s eyes cells, congenital systemic CMV, deafness. Supportice care and gancicolivir for immunocompromised patients.

Question 7

HHV-6 and HHV-7 Genome and envelope

Answer 7

dsDNA, envelope present (as in all HHV)

Question 8

HHV-6 and HHV-7 Tropism

Answer 8

CD4+ Tcells, epithelial cells and others

Question 9

HHV-6 and HHV-7 Pathologies and Tx.

Answer 9

Exanthem subitum (roseola), rash that develops after fever resolves. supportive tx and ganciclovir and cidofovir in imunocompromoised patients

Question 10

Epstein Barr Virus (HHV-4) Genome and envelope

Answer 10

dsDNA, envelope present (as in all HHV)

Question 11

Epstein Barr Virus (HHV-4) Tropism

Answer 11

Acute: epithelial cells of oropharynx
Latent: B cells

Question 12

Epstein Barr Virus (HHV-4) Pathologies and Tx.

Answer 12

EBV infectious Mono, Burkitt Lymphoma, Hodgkin and nonhodgkin lymphoma. x-linked lymphoproliferative disease: inherited mutation in SAP adapter. Tx. supportive for mono

Question 13

Kaposi Sarcoma herpes virus (HHV-8) Tropism

Answer 13

Epithelial cells, B cells

Question 14

Kaposi Sarcoma herpes virus (HHV-8) Pathologies and tx.

Answer 14

Is present in immunocompromised pts. only. kaposi sarcoma, primary effusion lymphoma, multifocal castleman’s disease. Tx. Ganciclovir, cidofir, foscarnet

Question 15

Parvovirus B19 Genome and Envelope

Answer 15

ssDNA, no envelope

Question 16

Parvovirus B19 Tropism

Answer 16

Erythroid Progenitor cells

Question 17

Parvovirus B19 Pathologies and Tx.

Answer 17

Slapped cheek syndrome, transient aplastic crisis in patients with underlying anemia. Tx. Supportive

Question 18

Human T Lymphotrophi Virus-1 Family, Genome, Envelope

Answer 18

Retroviridae, ssRNA, Yes

Question 19

Human T Lymphotrophi Virus-1 Tropism

Answer 19

T cells

Question 20

Human T Lymphotrophi Virus-1 Pathologies and tx.

Answer 20

Acute lymphoma/ leukemia, viral transcription factor Tax drives proliferation, blocks apoptosis. Inflammation on the spine. Tx. (chemotherapy/ bone marrow transplant)

Question 21

HIV-1 Family, Genome, Envelope

Answer 21

Retroviridae, ssRNA, enveloped

Question 22

HIV-1 Tropism

Answer 22

CD4+ T-cells, CD4+ monocytes, macrophages and others

Question 23

HIV-1 Pathologies and Treatments

Answer 23

AIDS, depletion of CD4 T cells allowing opportunistic infections. Tx. Multiple antiretroviral agents