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IHO > Viruses of the hematopoietic system > Flashcards

Viruses of the hematopoietic system Flashcards

1
Q

Colorodo Tick Fever Virus Envelope and Genome

A

No, and dsRNA

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2
Q

Colorodo Tick Fever Virus Tropism

A

proerythrocytes and mature RBCs

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3
Q

Colorodo Tick Fever Virus Pathologies and tx.

A

Sadleback fever pattern, tick resevoir Supportive,

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4
Q

Cytomegalovirus Family and Genome

A

Herpes HHV-5 and dsDNA

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5
Q

Cytomegalovirus Tropism

A

Systemic, latent in CD34+ cells (monocyte to macrophages)

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6
Q

Cytomegalovirus pathology and Tx.

A

CMV infectious mononucleosis. Owl’s eyes cells, congenital systemic CMV, deafness. Supportice care and gancicolivir for immunocompromised patients.

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7
Q

HHV-6 and HHV-7 Genome and envelope

A

dsDNA, envelope present (as in all HHV)

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8
Q

HHV-6 and HHV-7 Tropism

A

CD4+ Tcells, epithelial cells and others

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9
Q

HHV-6 and HHV-7 Pathologies and Tx.

A

Exanthem subitum (roseola), rash that develops after fever resolves. supportive tx and ganciclovir and cidofovir in imunocompromoised patients

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10
Q

Epstein Barr Virus (HHV-4) Genome and envelope

A

dsDNA, envelope present (as in all HHV)

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11
Q

Epstein Barr Virus (HHV-4) Tropism

A

Acute: epithelial cells of oropharynx
Latent: B cells

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12
Q

Epstein Barr Virus (HHV-4) Pathologies and Tx.

A

EBV infectious Mono, Burkitt Lymphoma, Hodgkin and nonhodgkin lymphoma. x-linked lymphoproliferative disease: inherited mutation in SAP adapter. Tx. supportive for mono

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13
Q

Kaposi Sarcoma herpes virus (HHV-8) Tropism

A

Epithelial cells, B cells

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14
Q

Kaposi Sarcoma herpes virus (HHV-8) Pathologies and tx.

A

Is present in immunocompromised pts. only. kaposi sarcoma, primary effusion lymphoma, multifocal castleman’s disease. Tx. Ganciclovir, cidofir, foscarnet

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15
Q

Parvovirus B19 Genome and Envelope

A

ssDNA, no envelope

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16
Q

Parvovirus B19 Tropism

A

Erythroid Progenitor cells

17
Q

Parvovirus B19 Pathologies and Tx.

A

Slapped cheek syndrome, transient aplastic crisis in patients with underlying anemia. Tx. Supportive

18
Q

Human T Lymphotrophi Virus-1 Family, Genome, Envelope

A

Retroviridae, ssRNA, Yes

19
Q

Human T Lymphotrophi Virus-1 Tropism

A

T cells

20
Q

Human T Lymphotrophi Virus-1 Pathologies and tx.

A

Acute lymphoma/ leukemia, viral transcription factor Tax drives proliferation, blocks apoptosis. Inflammation on the spine. Tx. (chemotherapy/ bone marrow transplant)

21
Q

HIV-1 Family, Genome, Envelope

A

Retroviridae, ssRNA, enveloped

22
Q

HIV-1 Tropism

A

CD4+ T-cells, CD4+ monocytes, macrophages and others

23
Q

HIV-1 Pathologies and Treatments

A

AIDS, depletion of CD4 T cells allowing opportunistic infections. Tx. Multiple antiretroviral agents

IHO (17 decks)

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