Theraputic Proteins Flashcards
Darbopoietin
Erythroid Growth factor Short half life. Used for chronic kidney disease, anemia. Side effects are thrombus, hypertension and increased tumor growth.
Erythropoietin
Erythroid Growth factor. Used for chronic kidney disease, anemia. Side effects are thrombus, hypertension and increased tumor growth.
M-Peg-epoetin
Erythroid Growth factor. Used for chronic kidney disease, anemia. Side effects are thrombus, hypertension and increased tumor growth.
Filgrastim
(G-CSF) Myeloid Growth factor. Used to make neutrophils, commonly used for cancer chemotherapy. Can have allergic reaction and splenic rupture, mild bone pain.
Pegfilgrastim
Myeloid Growth factor. Longer half life than Filgrastim, Used to make neutrophils, commonly used for cancer chemotherapy. Can have allergic reaction and splenic rupture, mild bone pain.
Sargramostim
(GM-CSF) Myeloid Growth factor. Stimulates all myeloid cell production. Can have capillary leak syndrome(edema), bone pain, fever, malaise, and occasionally allergic reaction.
Interleukin 11
Megakaryocyte Growth factor. Used to increase platelet production. Causes autoantibodies to be produced. Can cause A-Fib, and hypokalemia. May cause fatigue, headache, dizzyness, mild edema.
Romiplostim
Megakaryocyte Growth factor. Used to increase platelet production. Causes autoantibodies to be produced. Can cause A-Fib, and hypokalemia. May cause fatigue, headache, dizzyness, mild edema.
Most to least human
U, ZU, Xi, Mo(O) (Human, Humanized, Chimeric, Mouse) mouse also most likely to cause allergic/ other response.
Cir
Cardiovascular
vir
viral
lim
Immune
Les
infectious lesions
col
colon
mel
melanoma
