Antineoplastic Topics

Question 1

Efflux type pump for removal of drugs, especially natural drugs

Answer 1

P- glycoprotein

Question 2

Folate Analogs

Answer 2

Trex METHOTREXATE, PEMETREXED,

PRALATREXATE

Question 3

Antimetabolites

Answer 3

CITABINE and Arabine
CAPECITABINE, CLADARABINE,
CYTARABINE, FLUDARABINE,
GEMCITABINE

Question 4

Platinum containing cross linking agents

Answer 4

Platin

Question 5

Anthracycline antibiotics

Answer 5

RUBICIN
DAUNORUBICIN, DOXORUBICIN,
EPIRUBICIN, IDARUBICIN

Question 6

Nitrosoureas

Answer 6

MUSTINE
CARMUSTINE (BCNU), LOMUSTINE
(CCNU)

Question 7

Taxanes

Answer 7

TAXEL
PACLITAXEL, CABAZITAXEL,
DOCATAXEL

Question 8

Antibiotics

Answer 8

MYCIN

BLEOMYCIN, MITOMYCIN

Question 9

Camptothecins

Answer 9

TECAN

IRINOTECAN, TOPOTECAN

Question 10

Vinca alkaloids

Answer 10

VIN…INE
VINBLASTINE, VINCRISTINE,
VINORELBINE

Question 11

Signal transduction inhibitors (block the

actions of tyrosine kinases)

Answer 11

NIB
DASATINIB, ERLOTINIB, GEFITINIB,
IMATINIB, LAPATANIB, NALOTINIB,
PAZOPANIB, SORAFENIB, SUNITINIB

Question 12

Protein inhibitors

Answer 12

IB

BORTEZOMIB

Question 13

Vitamin B12

Answer 13

Is an important cofactor required for DNA synthesis and for maintenance of neurons and RBCs. It is critical cofactor in the generation of tetrahydrofolate from liver stores of tetrahydrofolate.

Question 14

Reduced Folate carrier

Answer 14

Is a high capacity, low affinity Transporter. Leukovorin is transported better than folate.

Question 15

Folate receptor

Answer 15

High affinity, low capacity system. Pinocytoses receptor to draw folate into the cell. Takes up folate better than methotrexate.

Question 16

Polyglutamination

Answer 16

Keeps folate in cell by adding glutamate on it. It also increases affinity for target cells. Cancer cells are better at polyglutamination

Question 17

Resistance to Alkylating agents

Answer 17

increase DNA repair, express gluathione (trapping agent)