Viruses and Prions

Question 1

Name the virus: Linear double stranded DNA with envelope:

Answer 1

Mononucleosis, Epstein Barr Virus

Question 2

Describe the anatomy of a naked virus (from outside in)

IMPORTANT!!

Answer 2

Capsid (made of capsomers)

Question 3

(IMPORTANT!!)

Describe the anatomy of an enveloped cell

Answer 3

VIRION= entire particle
particle

Envelope- outer membrane

Capsid- made of capsomers: protein that is the basis of the cell

Nucleocapsid: the naked virus

Nucleic Acid inside

Question 4

_____ interacts with viral nucleic acid for packaging and interacts with host receptors for entry into cell

Answer 4

The capsid

Question 5

What is the function of the nucleocapsid

Answer 5

Coats the nucleic acid

Question 6

Virus Protein Coat types

Answer 6

Icosahedral: Spherical: limited in the amount of nucleic acid it can fit

Helical: to limited to the amount of nucleic acid

Question 7

Describe the process of HIV infection

Answer 7

Double stranded RNA -> REVERSE TRANSCRIPTASE (contained in the virus)-> DOUBLE STRANDED DNA COPY -> IN THE NUCLEUS YOU HAVE POSITIVE STRAND

Question 8

Describe the process of HIV infection

Answer 8

Double stranded RNA -> REVERSE TRANSCRIPTASE (contained in the virus)-> Double stranded DNA -> positive sense RNA

Question 9

What does DNA polarity (sense mean)

Answer 9

+ sense= reading frame is 5-3

• sense= template strand

Question 10

What is the replication process for viruses?

Answer 10

-Innoculation, Eclipse, Burst, Burst Size

Question 11

Name the 5 classes of Herpes Virus and the DNA type

Answer 11

HSV-1
HSV-2
Varicella-Zoster
Cytomegalovirus 
Epstein-Barr- mono 

Enveloped viruses with double strand DNA genomes

Question 12

What does Epstein-Barr cause?

Answer 12

Mono

Question 13

What does CMV and EBV cause?

Answer 13

CVM: Infections mono, asymptomatic

EBV: Infectious mono

Question 14

What are 3 important classes of virus?

Answer 14

• Herpes virus
• influenza
• HIV

Question 15

Does influenza A or B cause pneumonia?

Answer 15

A

Question 16

What is the structure of influenza?

Answer 16

• Enveloped virus

- Segmented, single stranded RNA, negative sense

Question 17

HIV is a ____virus.

Answer 17

Retro-

Question 18

What are prions composed of?

Answer 18

Pure protein, no nucleic acids

Question 19

What is a major illness caused by Prions?

Answer 19

Transmissible Spongiform Encephalopathies

• Crueztsfeld- Jacob disease
• Kuru

Question 20

How are viruses grouped?

Answer 20

• Route of Infection
• Site of Disease
• Virus Family

Question 21

Are viruses in the GI tract enveloped on non-enveloped?

Answer 21

non-enveloped: acids destroy enveloped viruses

All enveloped viruses that enter through GI tract, sexual transmission are enveloped

Question 22

What are the two conformations of Prions?

Answer 22

Normal and Pathogenic