Antibiotics Flashcards
Name the broad spectrum antibiotics among protein inhibitors:
Protein Inhibitors:
- Tetracycline (30s)
- Lincosamide (Clindamycin) (50s)
Chloramphenicol (50s)
Streptogrammin (A and B) (50s)
What is the drug name for Lincosamide?
Clindamycin
What is the drug name for Macrolides?
Erthyromycin, Azythromycin
What is the drug name for Oxazolidenone?
Linezolid
What drug is highly associated with c. diffiicile?
Lincoamide (clindamycin)
What does tetracycline work against?
mycoplasma and intracellular bacteria
Are sulfonamides bacterio static or cidal?
Static
What drug binds to phosphotidal glycerol and what is it’s generic name?
Lipopeptides (Daptomycin)
Which drug is rarely used as a monotherapy due to the high incidence of target resistance?
Rifamycin- DNA dependent RNA polyerase mutates very quickly, should not be used alone
Which drugs can be used against Mycobacterium?
Izoniazid, Ethambutol, Aminoglycosides
What drug can be used for meningacoccal prohylaxis?
Rifampin
What are the bacteriocidal protein inhibitors?
Aminoglycosides, and sometimes Streptogramin (when A and B are combined)
What are the bacterioststic dna synthesis inhibitors?
Sulfonamides
Which drugs is highly effective against anaerobes?
Lincosamides and Nitroimidazoles
Name the pro-drug of the protein-inhibitors?
Nitroimidazole
Which drugs have prolonged Post antiobotic effects?
Flouroquinolones and Aminoglycosides
What is the post-antibiotic effect?
The time it takes for a bacteria to return to log phase growth after removal of the antibiotics
Define pharmacodynamics:
The drug’s effects on the body …
REMEMBER, begins with D.
Dynamic -> Drug
Define pharmacokinetics
The body’s effects on the drug
_______ can be either bacteriocidal or bacterostatic depending on the concentration.
Rifamycin
Describe the mechanism of action for Vancomycin
…
Describe the mechanism of action for Beta-Lactams and the ensuing resistance.
….
Broadly describe the avenues of resistance for bacteria.
1) Alter drug target
2) Decrease membrane permeability
3) Swamp the system
Name the 2 combinatorial therapies for anitbotics discussed in lecture
1) Beta Lactams and Aminglycosides
2) Sulfonamides and Trimethopime
Name the broad spectrum antibiotics among DNA synth. inhibitors:
DNA Inhibitors:
Sulfonamides (sulfamethoxone)
Nitromidazole (Metronidazole)
Flourquinone (Cipro)
