Antibiotics

Question 1

Name the broad spectrum antibiotics among protein inhibitors:

Answer 1

Protein Inhibitors:

• Tetracycline (30s)
• Lincosamide (Clindamycin) (50s)

Chloramphenicol (50s)

Streptogrammin (A and B) (50s)

Question 2

What is the drug name for Lincosamide?

Answer 2

Clindamycin

Question 3

What is the drug name for Macrolides?

Answer 3

Erthyromycin, Azythromycin

Question 4

What is the drug name for Oxazolidenone?

Answer 4

Linezolid

Question 5

What drug is highly associated with c. diffiicile?

Answer 5

Lincoamide (clindamycin)

Question 6

What does tetracycline work against?

Answer 6

mycoplasma and intracellular bacteria

Question 7

Are sulfonamides bacterio static or cidal?

Answer 7

Static

Question 8

What drug binds to phosphotidal glycerol and what is it’s generic name?

Answer 8

Lipopeptides (Daptomycin)

Question 9

Which drug is rarely used as a monotherapy due to the high incidence of target resistance?

Answer 9

Rifamycin- DNA dependent RNA polyerase mutates very quickly, should not be used alone

Question 10

Which drugs can be used against Mycobacterium?

Answer 10

Izoniazid, Ethambutol, Aminoglycosides

Question 11

What drug can be used for meningacoccal prohylaxis?

Answer 11

Rifampin

Question 12

What are the bacteriocidal protein inhibitors?

Answer 12

Aminoglycosides, and sometimes Streptogramin (when A and B are combined)

Question 13

What are the bacterioststic dna synthesis inhibitors?

Answer 13

Sulfonamides

Question 14

Which drugs is highly effective against anaerobes?

Answer 14

Lincosamides and Nitroimidazoles

Question 15

Name the pro-drug of the protein-inhibitors?

Answer 15

Nitroimidazole

Question 16

Which drugs have prolonged Post antiobotic effects?

Answer 16

Flouroquinolones and Aminoglycosides

Question 17

What is the post-antibiotic effect?

Answer 17

The time it takes for a bacteria to return to log phase growth after removal of the antibiotics

Question 18

Define pharmacodynamics:

Answer 18

The drug’s effects on the body …

REMEMBER, begins with D.

Dynamic -> Drug

Question 19

Define pharmacokinetics

Answer 19

The body’s effects on the drug

Question 20

_______ can be either bacteriocidal or bacterostatic depending on the concentration.

Answer 20

Rifamycin

Question 21

Describe the mechanism of action for Vancomycin

Answer 21

…

Question 22

Describe the mechanism of action for Beta-Lactams and the ensuing resistance.

Answer 22

….

Question 23

Broadly describe the avenues of resistance for bacteria.

Answer 23

1) Alter drug target
2) Decrease membrane permeability
3) Swamp the system

Question 24

Name the 2 combinatorial therapies for anitbotics discussed in lecture

Answer 24

1) Beta Lactams and Aminglycosides

2) Sulfonamides and Trimethopime

Question 25

Name the broad spectrum antibiotics among DNA synth. inhibitors:

Answer 25

DNA Inhibitors:

Sulfonamides (sulfamethoxone)

Nitromidazole (Metronidazole)

Flourquinone (Cipro)