Viruses 3 Flashcards
How many groups are there under the baltimore classification?
7
Different groups of baltimore viral genome makeup?
dsDNA, ssDNA dsRNA, +ssRNA, -ssRNA, ssRNA-RT, dsDNA-RT
Why is +ve sense mRNA so important for viral replicaiton?
It is the type of mRNA that can be translated
How do group 1 viruses work?
dsDNA
Uses its own or host DNA polymerases for replication
Example of group 1 virus?
Varicella zoster virus (chicken pox)
How do group 2 viruses work?
ssDNA (+ve sense)
Requires DNA pol to generate a complementary strand (dsDNA)
Example of group 2 virus?
Bacteriophages
How do group 3 viruses work?
dsRNA
Needs RNA-dependent RNA pol to make mRNA and genomic RNA
Where do group 3 and 4 viruses get RNA pol from?
Their own particle as it usually isn’t in the host cells
Example of group 3 virus?
Rotavirus, causes gastrointestinal disease
How do group 4 viruses work?
ssRNA (+ve sense)
Needs RNA-dependent RNA pol to make mRNA and genomic replication
Needs a -ve sense RNA intermediate
Example of group 4 virus?
Rhinovirus, coronavirus
How do group 5 viruses work?
ssRNA (-ve sense)
Needs RNA-dependent RNA pol to make mRNA and genomic replication
Difference between group 4 and 5 viruses?
4 needs to make a -ve sense RNA intermediate for translation to occur, 5 dont
Example of group 5 virus?
Rabies
How do group 6 viruses work?
Retroviruses (+ve ssRNA)
They have a reverse transcriptase to make dsDNA to facilitate viral replication
Example of group 6 virus?
HIV
Target for group 6 virus treatment?
Reverse transcriptase
How do group 7 viruses work?
dsDNA
use reverse transcriptase to make RNA from dsDNA
Example of group 7 virus?
Hepatitis B
