Antibiotics 2 Flashcards
1
Q
What does DNA gyrase do?
A
Produces -ve supercoils in the DNA–> unwinds DNA
2
Q
What does topoisomerase do?
A
Untangles DNA after replicaiton
3
Q
How does quinolones work?
A
Make a complex with DNA gyrase and topoisomerase
4
Q
Result of quinolones effect on DNA gyrase?
A
No supercoiled DNA or replication
5
Q
Result of quinolones effect on topoisomerase?
A
No decatenated DNA
6
Q
What do aminoglycosides inhibit in protein synthesis?
A
Proofreading and initiation–> toxic proteins are produced
7
Q
What does erythromycin inhibit?
A
Translocation
8
Q
What does tetracycline inhibit?
A
Binds to A site on the 30s subunit–> tRNA cannot enter
No protein synthesis
9
Q
What does chloramphenicol and lincosamides inhibit?
A
Transpeptidation
10
Q
Which bacteria is usually used to produce antibiotics?
A
Streptomyces
11
Q
A
