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PII > Viruses > Flashcards

Viruses Flashcards

1
Q

what type of virus is HIV

A

+ssRNA

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2
Q

what type of virus is Influenza A

A

-ssRNA

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3
Q

large dsDNA enveloped virus

A

Herpes

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4
Q

small DNA virus

A

HPV

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5
Q

virus that has 2 copies of the +ssRNA and host tRNA with it

A

HIV

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6
Q

virus that is segmented

A

Influenza A

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7
Q

what virus has RNA dependent RNA polymerase

A

influenza A

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8
Q

what virus has RNA dependent DNA polymerase

A

HIV

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9
Q

virus that turns itself from RNA to dsDNA

A

HIV

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10
Q

what enzyme binds viral genome into host genome

A

integrase

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11
Q

stage of HIV where patient presents with flu-like symptoms and viral load of anti-HIV Ab’s is high

A

stage I

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12
Q

stage of HIV where patient is asymptomatic and CD4+ levels can be slightly low or normal, and viral load is undetected

A

stage II

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13
Q

stage of HIV where CD4+ levels are low, patient has detectable viral load, and experiencing weird cancers/deterioration

A

stage III

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14
Q

2 really important opportunistic pathogens for HIV patients w/ AIDS

A

PCP (pneumocystis) and MAC

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15
Q

main drug cocktail used for HIV patients

A

2 NRTI’s + 1-2 PI’s

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16
Q

why can cardiovascular problems arise in patients who have been dealing w/ HIV for a long time?

A

due to anti-retroviral medications that increase their cholesterol

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17
Q

small DNA virus that has up to 200 different types

A

HPV

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18
Q

virus that has 2 capsid proteins and is naked

A

HPV

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19
Q

main players linked for transformation event causing cancer

A

E6 and E7
(E6-inhibits p53)
(E7-inhibits prb105)

20
Q

virus causes warts

A

HPV

21
Q

drug used to treat influenza A

A

oseltamivir (tamiflu)

22
Q

2 topical drugs used to treat warts (HPV)

A

Imiquimod
podoflox

23
Q

drug that turns TLR7 on and helps clearance of wart

A

imiquimod

24
Q

drug that arrests cell cycle and helps in clearance of wart

A

Podoflox

25
Q

HPV types ____and____are common causes of benign warts or benign head and neck tumors

A

6 and 11

26
Q

transformation event by HPV happens when…..and leads to uncontrollable proliferation

A

virus accidentally inserts itself into host genome

27
Q

target mucoepithelial cells and are latent in neurons

A

HSC-1, HSV-2, VZV

28
Q

target B cells and are latent in B cells

A

EBV

29
Q

target monocytes and lymphocytes and are latent in monocytes and lymphocytes

A

CMV

30
Q

this virus has DNA dependent DNA polymerase

A

HSV (herpes)

31
Q

main target for acyclovir (treats most herpes, not EBV or CMV)

A

thymidine kinase

32
Q

weird virus that buds off nucleus and then leaves cell by exocytosis

A

HSV (herpes)

33
Q

what causes herpes virus to be latent in neuron

A

LATs (latency-associated transcripts)

34
Q

what happens during reactivation of herpes

A

virus moves down same neuron and rapidly replicates

35
Q

direct analysis of HSV infection by scraping the base of a lesion

A

Tzanck smear

36
Q

look for multi-nucleated giant cells on what to diagnose HSV

A

tzanck smear

37
Q

2 markers for EBV

A

EBNA-1 and LMP-2a

38
Q

EBV infects B cell and causes it to make what kind of Ab’s

A

nonspecific IgM

39
Q

what cell (be specific) is EBV latent in

A

LMP-2a memory B cell

40
Q

triad: exudative pharyngitis, splenomegaly, and lymphadenopathy

A

EBV and CMV

41
Q

what distinguishes EBV from CMV

A

EBV is heterophile Ab + and CMV is Ab -

42
Q

difference b/t the cells seen in EBV and CMV

A

EBV: atypical (Downey)
CMV: cytomegalic cell

43
Q

immune response against EBV

A

T cells

44
Q

immune response against CMV

A

NK cells

45
Q

over the counter cream to help with HSV-1

A

Docosanol

46
Q

treatment for CMV

A

Ganciclovir

PII (10 decks)

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