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PII > Sepsis Lecture > Flashcards

Sepsis Lecture Flashcards

1
Q

metastatic lesions are a sign of what

A

septicemia

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2
Q

fever, rash, hypotension are signs of

A

shock

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3
Q

drug used against penicillin resistant staph

A

vancomycin

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4
Q

drug used against methicillin resistant staph

A

vancomycin

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5
Q

drug used against vancomycin resistant staph

A

oxolidinones (linezolid)

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6
Q

strep species involved in the normal oral microbiota

A

Streptococcus mutans

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7
Q

what protein involved w/ S. pyogenes is responsible for sequelae of RF and glomerulonephritis b/c it binds factor H and disrupts complement

A

M protein

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8
Q

what provides evidence of a previous Strep infection

A

high antistreptolysin O titers

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9
Q

hemolysin of strep that lyses blood anaerobically

A

Streptolysin O

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10
Q

strep exotoxins cause what through cytokine storm

A

toxic shock like syndrome (septic shock)

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11
Q

sx’s include confluent rash and strawberry tongue

A

scarlet fever

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12
Q

drug used to treat GAS

A

penicillin

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13
Q

drug used to treat syphillis

A

penicillin G

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14
Q

drug/s used to treat Group D strep

A

syngery b/t ampicillin and aminoglycoside

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15
Q

fever, altered mental status, hypotensive, petechial rash

A

Neisseria meningitis

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16
Q

gram - diplococci (kidney bean shape); oxidase +

A

Neisseria

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17
Q

what type of N. meningitis resembles K1 capsule of E. coli

A

type B

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18
Q

endotoxin (lipid A-LOS), carbohydrate capsule, pili, exotoxin cleaving IgA are virulence factors of

A

N. meningitis

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19
Q

what interaction activates clotting factors

A

lipid A binding to TLR4

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20
Q

usually starts as sore throat and is found in closed populations

A

N. meningitis

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21
Q

2 outcomes of meningococcemia:

A

gradual-sepsis
fulminating- clotting factors increased

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22
Q

petechiae and multisystem organ failure are signs of this

A

Disseminated intravascular coagulation

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23
Q

leads to adrenal hemorrhage and death

A

Waterhos-Friderichsen syndrome

24
Q

to treat N. meningitis

A

Ceftriaxone

25
Q

gram - rods that can cause septicemia or sepsis that are found in intestinal tract

A

Enterobacteriaceae

26
Q

high fever (>102), recent travel history to Mexico, sore throat, HA, diarrhea, abdominal tenderness (small pink papule rash); elevated liver enzymes; lactose non-fermenting gram - rod

A

Salmonella

27
Q

2 types of Salmonella enterica

A

serotype Typhi
serotype Choleraesuis

28
Q

S. enterica serotype Typhi causes:

A

Typhoid fever

29
Q

S. enterica serotype Choleraesuis causes:

A

Septicemia

30
Q

virulence factor for Salmonella Typhi

A

capsule Vi Ag

31
Q

fever, GI symptoms, rose spots, elevated liver enzymes

A

typhoid fever

32
Q

abrupt onset of fever w/ rapid rise, often no GI sx’s, metastatic infections

A

septicemia from S. choleraesius

33
Q

source of typhoid fever pathogen

A

contaminated food or water (fecal contamination)

34
Q

treatment for S. Typhi or Cholerasuis

A

Ceftriaxone

35
Q

treatment for Salmonella in carrier state

A

Amoxicillin or quinolones

36
Q

vaccine for typhoid fever targets what

A

Vi Ag capsule

37
Q

flu-like sx’s, LAD of axilla, recent travel history from Four Corners of New Mexico; prairie dogs, bipolar staining

A

Yersinia pestis (bubonic plague)

38
Q

gram - facultative intracellular pathogen; F1 capsule; bipolar staining

A

Y. pestis

39
Q

reservoir for Y. pestis

A

rodents

40
Q

vector for Y. pestis

A

flea

41
Q

To treat Bubonic plague

A

streptomycin, kanamycin
doxy

42
Q

gram - coccobacillus (think the radishes in sketchy); has lipid capsule

A

F. tularensis

43
Q

reservoirs for tularemia

A

rabbits

44
Q

vectors for F. tularemia

A

ticks and deerflies

45
Q

causes ulcer at site of infection; LAD

A

Tularemia

46
Q

to treat F. tularensis

A

aminoglycosides

47
Q

high fever, night sweats, travel history to Honduras, ate goat cheese, undulating fever (gram - coccobacillary)

A

Brucellosis

48
Q

2 oxidase + bacteria

A

Neisseria and Brucella

49
Q

reservoir for brucella

A

farm animals

50
Q

to treat Brucellosis

A

doxycycline and rifampin (think the wheel and old skinny man with rifle in sketchy)

51
Q

rigors, high fever, sob, dry cough, malaise, lung infiltrates, gram + rods

A

Bacillus anthracis—> anthrax

52
Q

peptide capsule of B. anthracis is composed of what

A

D-Glutamate

53
Q

ESCHAR; more susceptible if you work with animal hides

A

Anthrax

54
Q

anthrax toxin composed of what:

A

3 components
PA, EF, LF

55
Q

test used to detect spores in B. anthracis or C. difficile

A

PCR

56
Q

treatment of Anthrax

A

Cipro and Doxy (think sketchy pic)

PII (10 decks)

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