Virus pathologies Flashcards
Colorado tick fever: saddleback fever pattern; travel to mountain West
Colorado tick fever virus
CMV infectious mononucleosis: heterophile Ab negative; Owl’s eyes cells
Congenital systemic CMV: deafness
Cytomegalovirus (CMV; HHV-5)
exanthem subitum (aka roseola): rash that develops after a fever resolves heterophile Ab negative mononuceosis
HHV-6 & HHV-7
EBV infectious mononucleosis: Heterophile Ab positive mono
Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
nasopharyngeal lymphoma
X-linked lymphoproliferative disease: inherited mutation in SAP adapeter
Epstein Barr virus (EBV; HHV-4)
in immunocompromised patients only: Kaposi sarcoma, primary effusion lymphoma, multifocal Castlemans disease
Kaposi sarcoma herpes virus (KSHV; HHV-8)
erythema infectiosum: fiery red rash on cheek. Transient aplastic crisis: in patients with underlying anemia
parvovirus B19
Acute T cell lymphoma / leukemia (ATL): Viral transcription factor Tax drives proliferation; blocks apoptosis.
HAM/TSP: Inflammation on the spine
Human T lymphotrophi virus -1 (HTLV-1; related: HTLV-2)
Acquired immunodeficiency syndrome: depletion of CD4 T cells allows opportunistic infections
Human immunodeficiency virus -1 (HIV-1; related: HIV-2)
Hemorrhagic fever
Ebola virus (EBOV)