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IHO > Immunosuppressive Drugs > Flashcards

Immunosuppressive Drugs Flashcards

1
Q

Cyclosporine MOA

A

binds to CR protein cyclophilin and inhibitis calcineurin activity

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2
Q

Tacrolimus MOA

A

binds to CR protein FKBP and inhibits calcineurin activity

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3
Q

Sirolimus MOA

A

binds to FKBP and inhbits enzyme in cell cycle progression (mTOR)- blocks G1 to S

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4
Q

Mycophenolate Mofetil MOA

A

metaboite inhibits inosine monophosphate dehydrogenase (IMPDH)- important in guanine nucleotide synthesis - B and T cells highly dependent on

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5
Q

Anti-thymocyte globulin (ATG) MOA

A

binds to thymocytes in circulation and leads to lymphopenia and impaired T cell

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6
Q

Muromonab - CD3 MOA

A

Blocks antigen recognition on T cell receptor complex. Antibody binds to E chain

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7
Q

Daclizumab or Basiliximab MOA

A

binds to IL-2 receptor on activated T cells and blocks IL-2 mediated T cell activation

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IHO (12 decks)

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