Anti-inflammatory Drugs

Question 1

Diphenyhydramine MOA

Answer 1

Block H1, anti-muscarinic (affects acetylcholine) alpha adrenergic and serotonic

Question 2

Chlorpheniramine MOA

Answer 2

Block H1, muscarinic, alpha adrenergic and serotonic receptors

Question 3

Cetirizine MOA

Answer 3

H1(histamine) competitive antagonist

Question 4

Fexofenadine MOA

Answer 4

H1(histamine) competitive antagonist

Question 5

Loratadine MOA

Answer 5

H1(histamine) competitive antagonist

Question 6

Zileuton MOA

Answer 6

inhibits 5-lipoxygenase and prevents LTB4 and peptide leukotriene synthesis

Question 7

Zafirlukast MOA

Answer 7

leukotriene receptor antagonist LTD4 receptor + Cys LTR1.

Question 8

Montelukast MOA

Answer 8

leukotriene receptor antagonist LTD4 receptor + Cys LTR1.

Question 9

Acetylsalicylate

Answer 9

IRREVERSIBLY acteylates COX

Question 10

Ibuprofen

Answer 10

non-selective COX inhibitor (COX 1 and COX2)

Question 11

Naproxen

Answer 11

non-selective COX inhibitor

Question 12

Ketorolac

Answer 12

non-selective COX inhibitor

Question 13

Indomethacin

Answer 13

non-selective COX inhibitor

Question 14

Piroxicam

Answer 14

non-selective COX inhibitor

Question 15

Celecoxib

Answer 15

selective COX-2 inhibitor

Question 16

Acetominophen

Answer 16

weak inhibitor of COX - inhibits in brain but not at sites of inflamation