virulence factors Flashcards
staph aureus
- proteins that disable our immune sys (protien A)
- tissue tunnelling proteins
- exotoxin assault proteins
staph epidermidis
biofilms
grp A beta hemolytic strep (strep pyrogens)
- M protein
- streptolysin O enz
- streptolysin S enz
strep pnemoniae
polysaccharide capsule: prevent phago
bacillus anthracis
unique protein capsule from pOX2, which releases exotoxins:
- edema factor - increases cAMP
- protective ag - promote EF into mfs
- lethal factor - TNF death
bacillus cereus
enterotoxins:
- heat labile toxin
- heat stable toxin
clostridium tetani
tatanospasmin –>tetany of m’s
clostridium botulinum
neurotoxin that blocks Ach release –> flaccid paralysis
clostridium difficile
exotoxin A: diarrhea
exotoxin B: cytotoxic to colonic cells
clostridium perfringens
exotoxins that affect tissue, m, gut
cornybacterium diptheriae
exotoxins that target the <3 and brain
listeria monocytogenes
listeriolysin O: avoid phagolysosomes
neisseria meningitides
- capsule
- endotoxin
- IgA1 protease
- steal Fe from humans
- pilli
neisseria gonorrhoeae
- pilli
- outer mem proteins
- opa proteins
e coli
- mucosal interaction: able to invade
- exotoxins:heat labile and heat stable and shiga-like toxin
- LPS endotoxin
- takes Fe from human transferrin or lactoferrin
yersina enterocolitica
enterotoxin
campylobacter jejuni
toxin similar to LT
vibrio cholera
choleragen –> NaCl to lose water and elcs
Pseudomonas aeruginosa
exotoxin A; capsule
bordatella pertussis
- pertussis toxin
- extracytoplasmic adenylate cyclase
- Filamentous hemagglutin
- tracheal cytotoxin
mycobacterium tuberculosis
- cord factor
- sulfatides
- waxD
treponema
none, just use our own immune sys against us
yersina pestis
- fraction 1 (capsule ag that resists phago)
- v and w ag
