Virulence Factor Flashcards

1
Q

Colonizes anterior mares, nasopharynx, perianal area, skin, mucosa

A

Staph aureus

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2
Q

Skin flora, assoc with bacterial endocarditis ff prosthetic heart valve, blood culture contaminant, hospital acquired UTI

A

Staph epidermidis

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3
Q

Flora of skin, genito urinary tract and mucosa. Most common uti in sexually active fem

A

Staph saprophyticus

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4
Q

Virulence factor causes scalded skin syndrome

A

Exfoliative toxin : serine protease

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5
Q

Ritters disease 90% of body is affected or Perphigus neonatorum/bullos impetigo

A

Staph aureus: exfoliative toxin/ epidermolytic toxin

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6
Q

Toxic to wbcs initiating deeper tissue infection

A

Gamma toxin: Panton Valentin Leukocidin

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7
Q

Induces IL1 secretion causing fever, vomiting, rash and hypotension lead to shock and death

A

Staph aureus
Entero toxin F: Toxic shock syndrome toxin 1

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8
Q

Virulence factor of Staph aureus digests connective tissue matrix

A

Hyaluronidase: Duran Reynal Factor/ Spreading factor

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9
Q

Treatment for MRSA

A

Vancomycin

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10
Q

Subsurface hemolysin oxygen labile. Toxic to RBCs, WBC, and platelets

A

Streptolysin O

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11
Q

Induces antibody response Anti streptolysin O.stab inside the gel agar anaerobe

A

S.pyogenes: Strep O

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12
Q

Surface antigen oxygen stable. Lysis WBCs and non immunogenic

A

Strep pyogenes: Streptolysin S

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13
Q

Associated with SCARLET FEVER and Strep Toxic Like syndrome

A

Strep Exotoxin ABC SPE
Exotoxin A
Strep.pyogenes

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14
Q

Post streptococcal sequelae. Common infections of Strep pyogenes

A

Rheumatic heart fever
Acute glomerulonephritis

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15
Q

Cross reactive antibodies agains streptococcal antigens and human heart tissues alike. Causes fever and inflammation of heart and blood vessels

A

Rheumatic heart fever by strep pyogenes

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16
Q

Protein that able to bind beta globulin factor H, cant degrade alternate pathway activation of immune system

A

M protein of Strep pyogenes

17
Q

Bacterial pharyngitis and tonsilitis

A

Strep pyogenes

18
Q

Neonatal meningitis

A

Strep agalactiae

19
Q

Causes pneumonia, obstetric complications during delivery. Endometritsmis and woubd infection

A

Strep agalactiae

20
Q

Resembles Strep pyogenes infections. Large Beta hemolytic colonies

A

Grp C: Strep dysgalactiae sub equisimilis

21
Q

Nosocomial infection UTI catherization, bacteremia (hemodialysis, surgery) endocarditis (prothetic heart valves)

A

Grp D enterococcos

22
Q

Causes subacute bacterial endocarditis from patient with damaged heart valves. Causes bacteremia, septicemia and cavities

A

Viridans Strep Grp ACFGN

23
Q

Assoc disease. Lobar and community acquired pneumonia
Causes sinusitis, otitis media, bacteremia

A

Strep pneumoniae

24
Q

Meningitis aged group affected by Strep pneumoniae

A

30 to 99
Late adult

25
Neonates meningitis causative agents
1. Strep agalactiae 2. E.coli 3. L.monocytogenes
26
1 to 5 years old meningitis
Haemophilus influenzae
27
Adult to old aged or immunocompressed people meningitis CA
1. Strep pneumoniae 2. Staph aureus
28
most common agents through nasopharyngeal swab
1. H.influenzae 2. N.meningitidis 3. B.pertussis 4. MRSA 5. Diphtheriae