Virology

Question 1

Positive strand RNA Viruses

Answer 1

RETRO TOGA party FLAV CORONA / HIPPY CALI PICkles

Question 2

naked viral genome (non-enveloped)

Answer 2

give PAPP smears + CPR to naked Heppy.

DNA = Papillomavirus, Adenovirus, Parvovirus, Polyomavirus

RNA = Calicivirus Picornavirus
Reovirus + Hepevirus

Question 3

viral envelopes

Answer 3

enveloped viruses acquire envelopes from PLASMA membrane.

herpesvirus acquires envelopes from the NUCLEAR membrane

Question 4

DNA viruses

Answer 4

1) HHAPPPPy = Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma

2) ds
3) linear
4) icosahedral
5) replicates in the nucleux

Question 5

special things about pox

Answer 5

complex DNA that carries its own DNA-dependent RNA pollymerase

Question 6

Naked RNA viruses

Answer 6

reovirus / picornavirus

Question 7

negative-stranded viruses

Answer 7

must transcribe negative to positive strand. virion brings its own RNA-dependent RNA polymerase.

Question 8

Always Bring Polymerase Or Fail Replication

Answer 8

Arena
Bunya
Paramyxo
Orthomyxo
Filo
Rhabdo

Question 9

segmented viruses

Answer 9

RNA viruses: BOAR

1) Bunya
2) Orthomyxo (influenza)
3) Arena
4) Reo

Question 10

Picornavirus

Answer 10

PERCH

1) Polio
2) Echo
3) Rhino
4) Coxsackie
5) HAV

one large polypeptide cleaved into functional viral proteins.

fecal-oral enteroviruses

*may cause aspetic meningitis except rhino / HAV

Question 11

yellow fever

Answer 11

flavi transmitted by Aedes mosquito w/ monkey reservoir

symptoms: fever, black vomitus, jaundice

Question 12

rotavirus

Answer 12

infantile gastroenteritis –> segmented reovirus (dsRNA) –> acute diarrhea.

1) villous destruction w/ atrophy –> dec. Na / K+ absorption

Question 13

paramyxoviruses

Answer 13

1) affect children
2) all contain F protein –> respiratory epithelial cells fuse and form multinucleated cells
3) palivizumab antibody prevents pneumonia in premature infants

Question 14

measles

Answer 14

1) cough
2) Koplik spots
3) conjunctivitis

descending maculopapular rash.

Question 15

sequelae of measles

Answer 15

1) SSPE (subacute sclerosing panencephalitis
2) encephalitis
3) giant cell pneumo

Question 16

vitamin supplementation in measles

Answer 16

vita A prevents severe exfoliative dermatitis in malnourished children

Question 17

Mumps

Answer 17

parmyxovirus:

1) parotitis
2) orchitis
3) aseptic Mengingitis –> may lead to sterility

Question 18

prions

Answer 18

conversion of alpha-helical protein into beta-pleated –> ransmissible protease resistance.

spongiform encephalopathy, dementia, ataxia, death.

sporadic = creutzfeldt-jakob
inherited = gerstmann-straussler-scheniker syndrome

Question 19

UTI diagnostic tests

Answer 19

+ leukocyte esterase = bactericidal
+ nitrite = gram-neg
+ urease = proteus / klebsiella
- urease = e. coli / enterococcus