Random Facts MHC / HLA

Question 1

MHC I binds

Answer 1

TCR / CD8

Question 2

MHC II binds

Answer 2

TCR + CD4

Question 3

MHC I expression on cells

Answer 3

all nucleated cells (no RBCs)

Question 4

MHC II expression on cells

Answer 4

APCs

Question 5

MHC I function

Answer 5

endogenously syntheized antigens (viral) to CD8+ cototoxic T cells

Question 6

MHC II function

Answer 6

exogenously synthesized proteins (bacterial proteins, viral capside proteins) to T-helper cells

Question 7

HLA A3

Answer 7

hemochromatosis

Question 8

HLA B27

Answer 8

PAIR (seronegative arthropathies): psoriatic arthritis, ankylosing spondylitis, IBD, reactive arthritis

Question 9

HLA DQ2/DQ8

Answer 9

celiac disease

Question 10

HLA DR2

Answer 10

MS, hay fever, SLE, goodpasture

Question 11

HLA DR3

Answer 11

DM1, SLE, graves

Question 12

HLA DR4

Answer 12

rheumatoid arthritis, DMI

Question 13

HLA DR5

Answer 13

pernicious anemia –> vit B12 deficiency; hashimoto thyroiditis

Question 14

anti-cardiolipin

Answer 14

SLE

Question 15

anti-desmoglein

Answer 15

pemphigus vulgaris

Question 16

anti-glutamate decarboxylase

Answer 16

DM1

Question 17

anti-histone

Answer 17

drug-induced lupus

Question 18

anti-Jo, antiSRP-antiMi2

Answer 18

polymyositis, dermatomyositis

Question 19

antimicrosomal/antithyroglobulin

Answer 19

hashimoto thyroiditis

Question 20

anti-scl-70 / anti-DNA topoisomerase I

Answer 20

scleroderma

Question 21

anti-SSA, anti-SSB

Answer 21

sjogren syndrome

Question 22

anti-U1 RNP

Answer 22

mixed connective tissue disease

Question 23

c-ANCA / PR3-ANCA

Answer 23

granulomatosis w/ polyangiitis

Question 24

IgA antiendomysial / IgA anti-tissue transglutaminase

Answer 24

celiac disease

Question 25

p-ANCA / MPO-ANCA

Answer 25

microscopic polyangiitis / Churg-Strauss syndrome