Random Facts MHC / HLA Flashcards
1
Q
MHC I binds
A
TCR / CD8
2
Q
MHC II binds
A
TCR + CD4
3
Q
MHC I expression on cells
A
all nucleated cells (no RBCs)
4
Q
MHC II expression on cells
A
APCs
5
Q
MHC I function
A
endogenously syntheized antigens (viral) to CD8+ cototoxic T cells
6
Q
MHC II function
A
exogenously synthesized proteins (bacterial proteins, viral capside proteins) to T-helper cells
7
Q
HLA A3
A
hemochromatosis
8
Q
HLA B27
A
PAIR (seronegative arthropathies): psoriatic arthritis, ankylosing spondylitis, IBD, reactive arthritis
9
Q
HLA DQ2/DQ8
A
celiac disease
10
Q
HLA DR2
A
MS, hay fever, SLE, goodpasture
11
Q
HLA DR3
A
DM1, SLE, graves
12
Q
HLA DR4
A
rheumatoid arthritis, DMI
13
Q
HLA DR5
A
pernicious anemia –> vit B12 deficiency; hashimoto thyroiditis
14
Q
anti-cardiolipin
A
SLE
15
Q
anti-desmoglein
A
pemphigus vulgaris
