Virology Flashcards
Class of antiviral drug to which acyclovir belongs
Nucleoside analogue
Interferes with DNA polymerase causing chain termination and an incomplete sugar ring.
Role of HIV in malignancy
HIV not oncogenic. Immunosuppression increases chance of viral persistence/expansion. This allows for acquisition time for mutations and cells may undergo malignant change.
What may provoke HSV reactivation
Sunlight Stress Febrile illness Menstruation Immunosuppression
How to diagnose HSV
Usually clinically IgG - evidence of exposure IgM - poor marker Culture PCR - CSF or blood
High risk HPV types
16,18,31,33,45
Two available HPV vaccines
Gardasil - high and low
Cervarix - high only
Intra uterine only infection
Parvovirus
Rubella
Syphilis
Toxoplasma g
Intrauterine, intrapartum and noenatal infections
Varicella zoster HIV Hep B HSV CMV Coxsackie B
Intrapartum only infection
Papillomavirus
Gonococcus
Chlamydia t
Why neonatal infections so persistent
Lack of mature immune system
Clearance occurs late/never
Ongoing disease after birth
