Immunology Flashcards
0
Q
Pathogenesis of type l diabetes
A
Genetic (HLA-DR3/4) + environmental factors + autoimmune insulitis = B cell destruction
1
Q
Four main aspects of mosaic autoimmunity
A
Genetics (HLA A1, B8, DR3)
Environment (infection, drugs, UV, toxins, cosmetics)
Sex (female, more IG and CMI, males more prone to infection)
Immune deficiency (IgA def)
2
Q
Type l hypersensitivity reaction
A
Immediate IgE
3
Q
What type of hypersensitivity disease is diabetes
A
T cell mediated (type lV)
4
Q
B lymphocyte defect of newborn egs
A
X-linked agammaglobulinaemia CD40 ligand deficiency IgA def Common variable immunodeficiency CVID Transient hypogammaglobulinaemia of infancy
