Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Semester 5 April > Virology > Flashcards

Virology Flashcards

0
Q

Routes of infection in pregnancy

A

Intrauterine (transplacental/ ascending after PROM)
Intrapartum
Neonatal/ post partum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Why infections common in pregnancy?

A

Poor CMI

Hyper metabolic state.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Symptoms of rubella infection

A

LARF

LN, arthritis, rash and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When does rubella infection of fetus occur

A

First trimester

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why is rubella so teratogenic

A

Low pathogenicity = doesn’t kill fetus outright.

Interferes with specific organogenesis (ESP organ of corti)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Vaccine for rubella

A

Live attenuated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Specific abnormalities of newborn with rubella

A

Neuro sensory deafness, cataracts, microphthalmia, Microcephaly, mental retardation
PDA, late type 1 diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pathogenesis of parvovirus in fetus

A

Resp droplet spread. Replicates in RBC precursors. Transient RBC synthesis arrest. Aplastic crisis. (Fine for healthy not for HIV, B cell defs, blood cancers)
Fetal anaemia and cardiac failure > hydrops fetalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Symptoms of parvovirus

A

BARF

Blood complications, arthritis, rash, fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When is HIV most likely to be given to baby

A

Intrapartum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why is congenital infection diagnosis so NB

A 
Determine risk
Offer termination (eg Rubella)
Give intervention (eg blood transfusion in parvovirus)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Modes of congenital infection prevention

A
  1. Screening
  2. Avoid exposure
  3. C/S at delivery
  4. Vaccines/ Igs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Rx for syphilis

A

Benzathene penicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Rx for neonatal herpes/VZV

A

Acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Specific feature of toxoplasma infection in newborn

A

Chorioretinitis
Cerebral calcifications
Seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What causes ophthalmia neonatarum

A

Gonococcus

Chlamydia

16
Q

Rx HSV 1/2

A

Acyclovir

17
Q

Primary infections in HSV

A 
Gongivostomatitis
Eczema herpeticum
Herpetic whitlow
Conjunctivitis, keratitis
Genital herpes
18
Q

Reactivation of HSV

A

Cold sores
Recurrent genital herpes
Keratitis
Aseptic meningitis

19
Q

Rare life threatening syndromes in HSV

A

Acute necrotising encephalitis
Neonatal infection ( cutaneous, general, encephalitis)
Disseminated HSV

20
Q

Who get VZV vaccine

A

Children >1year

<72hrs post exposure

21
Q

Who gets post exposure zoster immunoglobulin

A

Immunocomprimsed
<6months
Pregnant woman

22
Q

Complications in varicella infection

A 
Stroke (most common cause in kids)
Secondary infection of skin lesions
Post infectious encephalomyelitis 
Pneumonia
Haemorrhagic varicella
Congenital varicella syndrome
23
Q

Complications of zoster infection

A

Post herpeticum neuralgia

Ramsay hunt syndrome (trigeminal branch, unilateral facial palsy, ear pain, vesicles on external ear)

24
Q

Rx of CMV

A

Gancyclovir in severe immunocomprimsed pts

25
Q

Clinical features of CMV infection of neonate

A

Generalized infection (cytomegalic inclusion disease)
Deafness, MR, jaundice, HSM, Microcephaly, haemolytic anaemia, thrombocytopenia
Owl eye inclusions

26
Q

Pathogenesis of EBV infection

A

Primary infection -> latency in B lymphocytes (or epithelium) -> reactivation

27
Q

Testing for EBV

A

Monospot heterophile Ab agglutination

Viral capsid and nuclear Ag tests

28
Q

Clinical manifestations of EBV

A

Infectious mononucleosis
Burkitt’s and nonburkitt’s
Nasopharyngeal Ca
Hairy leukoplakia

29
Q

Clinical manifestations of HHV 6/7

A 
Rosoela infantum
Infectious mononucleosis like illness
Immunocomprimsed :
Interstitial pnumonitis
Encephalitis
30
Q

Clinical manifestations of HHV 8

A

Karposis sarcoma
Primary effusion lymphomas
Multi centric castleman’s disease

31
Q

Clinical manifestations of HPV infection

A 
Cutaneous warts (1,2,3,4,5,8)
Mucosal warts (6,11) [laryngeal papilloma]
Cervical cancer (16,18,31,33,45)
Epidermodysplasia verruiformis
32
Q

Rx of Hep B

A

Interferons

Nucleoside reverse transcriptase inhibitors

33
Q

Cancer associated with Hep B

A

HCC

Fish factors [early exposure, cocarvinogens - Fe overload, alcohol, aflatoxins]

34
Q

Cancer associated with HTLV1

A

T cell leukaemia/lymphoma

35
Q

Viral cause of skin cancer

A

Merkel cell polyomavirus

Semester 5 April (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions