Viral URIs Flashcards
Enveloped DNA virus that targets CD21 receptor on B cells
EBV
IgG and absence of EBNA in EBV
Chronic primary infection
IgM for EBV
Acute primary infection
IgG and EBNA for EBV
Past infection
Treatment for EBV
Antipyretics
Refrain from contact sports
Complications of EBV
Splenic rupture
Latency
Enveloped DNA virus that remains latent in ganglion
HSV
Complications of HSV in immunocompromised
Dissemination
Herpes encephalitis
Pt presents with vesicular lesion on around the mouth, ulcerative lesions with grayish exudate on the oral mucosa and pharynx, erythema of pharynx with whitish exudate, and lymphadenopathy
HSV
Stain used for seeing multinucleated giant cells in HSV
Tzanck smear
Treatments for HSV
Acyclovir
Nucleoside analog
Some possible CMV presentations in immunocompromised
CMV hepatitis
CMV retinitis
Interstitial pneumonia
Characteristic histology finding in CMV
Owl’s eye inclusion body
Morphology of HSV
Enveloped dsDNA virus
Pt presents with erythematous pharynx with exudate, non-purulent conjunctivitis, and mild blanching rash on cheeks and torso. They swim regularly at a public pool.
Adenovirus - pharyngoconjunctival fever
Complications of adenovirus in immunocompromised
Serious pneumonia
Hepatitis
Infections that can be caused by adenovirus
Pharyngoconjunctival fever
Acute respiratory distress
Epidemic keratoconjunctivitis
Diarrhea
Cystisis
Icosahedral non-enveloped DNA virus that targets the mucosal epithelium of the respiratory tract and conjunctiva
Adenovirus
In which part of the cell does adenovirus replicate?
Within the nucleus
Non-enveloped RNA virus that presents as shallow yellow ulcers surrounded by red halos in the oral mucosa
Coxsackie A
Child presents with thick-walled gray vesicles on an erythematous base on the palmar and plantar surfaces of the hands, on the face, and on the buttocks
Coxsackie A
Herpangina
Coxsackie A only with ulcers in the mouth
Medication contraindicated in Coxsackie A
Steroid
Uncommon causes of pharyngitis
HIV
Toxoplasma
Mycoplasma pneumoniae
Gonococcal
Complications of otitis media
Ruptured TM
Chronic suppurative otitis media
Mastoiditis
Treatments for otitis media
Amoxicillin
3rd gen cephalosporin
Small, pleomorphic, gram-negative, coccobacillary rods with fastidious growth requirements
H influenzae
Requirements for growth of H influenzae
X/hemin and V/NAD –> chocolate agar
How will H influenzae grow on blood agar?
If in the presence of S aureus, X and V
Satellitism
Risk factors for malignant otitis externa
DM
Immunocompromised elderly
Severe necrotizing infection that spreads from squamous epithelium of ear canal to adjacent areas of soft tissue, blood vessels, cartilage, and bone
Malignant otitis externa
Life threatening complication of malignant otitis externa
Spread to temporal bone, sigmoid sinus, or base of skull
Treatment for otitis externa
Debridement
Ear drops –> fluoroquinolone, neomycin, hydrocortisone
Treatment for malignant otitis externa
Ceftazidime or cefepime
Piperacillin + aminoglycoside
Fluoroquinolone
Carbapenem
Gram negative diplococci without a capsule. Grows well on blood agar. Produces beta lactamase
Moraxella catarrhalis
Possible infections caused by Moraxella catarrhalis
Otitis media
Sinusitis
COPD exacerbations
Non-enveloped, positive sense, ssRNA virus that has optimum replication of 32 C
Rhinovirus
How does rhinovirus attach to nasal or pharyngeal epithelium?
ICAM-1
Inflammatory factors that cause hyperemia and edema in rhinovirus infection
IFN-alpha and IFN-beta
Complications of a cold
Sinusitis
Otitis media
Tracheobronchitis