Intro to respiratory infections Flashcards
8 yo pt presents with sore throat. On mouth exam there is scattered petechiae, red edematous exudative tonsils, and red strawberry tongue
Group A strep
Gram positive cocci in chain with beta hemolysis on blood agar. Catalase negative. Bacitracin sensitive
Group A strep
Suppurative complications of GAS
Peritonsillar abscess
Cervical lymphadenitis
Non-suppurative immune mediated complications of GAS
Acute rheumatic fever
Acute post-strep glomuronephritis
Treatments for GAS
Penicillin or Amoxicillin
Cephalosporin - if penicillin allergy
Erythromycin
Clindamycin
GAS virulence factor that binds to serum factor H and inhibits complement activation and C3b mediated opsonization
M protein
Pathogen that has Lancefield antigen A cell wall carbohydrate antigen as one of its virulence factors
GAS
Clot buster of GAS
Streptokinase
Spreading factor of GAS that breaks down CT
Hyaluronidase
Adhesion virulence factors of GAS
Lipoteichoic acid
F protein
Blood test for rheumatic fever
ASO titer that measures antibodies to streptolysin O
Pt presents with strep throat. On exam there is thick, dirty gray, leathery pseudomembrane on the pharynx
Diphtheria
Small, pleomorphic, club-shaped, gram positive, aerobic rods that form a palisade pattern
Corynebacterium diphtheria
Selective medium for C diphtheria
Potassium tellurite blood agar (Tinsdale) - grows as black colonies
Virulence factor of diphtheria that inhibits protein synthesis by ADP phosphorylation of EF-2
Exotoxin A-B
