Viral hepatitis

Question 1

Laboratory diagnosis

Detection of specific immune response for this procedure igms are indicators of

Answer 1

acute or recent infection

Question 2

Laboratory diagnosis

Detection of specific immune response for this procedure iggs are indicators of

Answer 2

past infection
immunisation response
presence of passively acquired antibody after receiving
blood products

Question 3

what is viral hepatitis

Answer 3

inflammation of liver,
Wide spectrum of clinical disease :
asymptomatic, mild, fulminant, death

Question 4

what viruses can cause of viral hepatitis

Answer 4

hep a-e viruses, ebv, cytomegalovirus,

Question 5

does hep a cause chronic infection

Answer 5

no

Question 6

when can hep e cause chronic infection

Answer 6

in immunocompromised individuals

Question 7

which hep virus cause chronic infewction

Answer 7

bcd

Question 8

what are symptoms of viral hepatitis

Answer 8

malaise fever headaches, anorexia, vomiting nausea, right upper quadrant pain(big sign), jaundice(big sign), dark urine and clay faeces

Question 9

how do you manage viral hepatitis

Answer 9

contact public health england, supportive care, antivirals, isolation, active and passive immunistation

Question 10

what are the similarities between hep a and e

Answer 10

Route of transmission
• Incubation period
• Laboratory diagnosis

Question 11

describe the vrius that causes hep a and its incubation period

Answer 11

ss rna uneveloped hepatovirus, 3-5 week

Question 12

how can you prevent and control hep a

Answer 12

Jaundice : considered infectious from 2 weeks before to 7 days after
jaundice onset
• Sanitary disposal of waste
• Good hygiene
• Active immunisation - hepatitis A vaccine
• Passive immunisation - Human Normal Immunoglobulin

Question 13

Hepatitis E virus infection describe virus and transmission

Answer 13

ss RNA unenveloped virus,
Foodborne zoonosis
• Undercooked meat products ie pork sausages
• Evidence of transmission by blood transfusion

Question 14

what is incubation period of hep b

Answer 14

2.5 months average

Question 15

describe the virus causing hep b

Answer 15

ds dna hepatovirus

Question 16

how is hep b transmitted

Answer 16

sex, tattoo, piercings, drug use

Question 17

acute infection of the liver can lead to which two states

Answer 17

icteric which resolves or anicteric

Question 18

what is anicteric

Answer 18

carrier state, progresses to cirrhosis then can result in hepatocellular carcinoma

Question 19

Pathogenesis of liver injury in infection

Answer 19

viral replication and cell mediated cytotoxicity, host chromosomal integration

Question 20

how can you passively immunisise against hep b

Answer 20

Hepatitis B Immunoglobulin (HBIG) provided

Question 21

how can you actively prevent hep b

Answer 21

• Active immunisation

Question 22

why are hcw given hep b injection

Answer 22

• Hepatitis B transmission from HBV infected HCWs to patients during
exposure prone procedures (EPPs) is well documented. preventative measure

Question 23

does hep c have a vaccination

Answer 23

no

Question 24

how do you diagnose hep c

Answer 24

hcv antibody,
Molecular diagnostic tests
• HCV RNA detection and quantification
• HCV genotype
• Antiviral resistance

Question 25

what is hep c incubation period

Answer 25

6-12 weeks

Question 26

how is hep c transmitted

Answer 26

Injecting drug users sharing equipment, blood and blood products, contaminated needles
ie tattooing, body piercing, not as likely via sex or vertical route(mum to child)

Question 27

describe the virus causing hep c

Answer 27

ss rna enveloped flavivirus