Viral hepatitis Flashcards
Laboratory diagnosis
Detection of specific immune response for this procedure igms are indicators of
acute or recent infection
Laboratory diagnosis
Detection of specific immune response for this procedure iggs are indicators of
past infection
immunisation response
presence of passively acquired antibody after receiving
blood products
what is viral hepatitis
inflammation of liver,
Wide spectrum of clinical disease :
asymptomatic, mild, fulminant, death
what viruses can cause of viral hepatitis
hep a-e viruses, ebv, cytomegalovirus,
does hep a cause chronic infection
no
when can hep e cause chronic infection
in immunocompromised individuals
which hep virus cause chronic infewction
bcd
what are symptoms of viral hepatitis
malaise fever headaches, anorexia, vomiting nausea, right upper quadrant pain(big sign), jaundice(big sign), dark urine and clay faeces
how do you manage viral hepatitis
contact public health england, supportive care, antivirals, isolation, active and passive immunistation
what are the similarities between hep a and e
Route of transmission
• Incubation period
• Laboratory diagnosis
describe the vrius that causes hep a and its incubation period
ss rna uneveloped hepatovirus, 3-5 week
how can you prevent and control hep a
Jaundice : considered infectious from 2 weeks before to 7 days after
jaundice onset
• Sanitary disposal of waste
• Good hygiene
• Active immunisation - hepatitis A vaccine
• Passive immunisation - Human Normal Immunoglobulin
Hepatitis E virus infection describe virus and transmission
ss RNA unenveloped virus,
Foodborne zoonosis
• Undercooked meat products ie pork sausages
• Evidence of transmission by blood transfusion
what is incubation period of hep b
2.5 months average
describe the virus causing hep b
ds dna hepatovirus
how is hep b transmitted
sex, tattoo, piercings, drug use
acute infection of the liver can lead to which two states
icteric which resolves or anicteric
what is anicteric
carrier state, progresses to cirrhosis then can result in hepatocellular carcinoma
Pathogenesis of liver injury in infection
viral replication and cell mediated cytotoxicity, host chromosomal integration
how can you passively immunisise against hep b
Hepatitis B Immunoglobulin (HBIG) provided
how can you actively prevent hep b
• Active immunisation
why are hcw given hep b injection
• Hepatitis B transmission from HBV infected HCWs to patients during
exposure prone procedures (EPPs) is well documented. preventative measure
does hep c have a vaccination
no
how do you diagnose hep c
hcv antibody, Molecular diagnostic tests • HCV RNA detection and quantification • HCV genotype • Antiviral resistance
what is hep c incubation period
6-12 weeks
how is hep c transmitted
Injecting drug users sharing equipment, blood and blood products, contaminated needles
ie tattooing, body piercing, not as likely via sex or vertical route(mum to child)
describe the virus causing hep c
ss rna enveloped flavivirus
